In vivo imaging of embryonic cell death in the new model animal and its molecular analysis
In vivo imaging of embryonic cell death in the new model animal and its molecular analysis
批准号:
21570223
负责人:
SAKAMAKI Kazuhiro
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2012
中文摘要
FADD是一种在细胞内传递凋亡信号的接头蛋白。在这项研究中,我们已经证明了FADD在非洲爪哇胚胎中具有多种功能;它在心脏形成和细胞凋亡中发挥作用。我们还建立了一个表达生物传感器的转基因青蛙品系,该生物传感器适合于检测死亡细胞,并观察了该生物传感器在胚胎发育过程中诱导细胞凋亡时的变化。
英文摘要
FADD is an adaptor protein that transmits apoptotic signals in the cell. In this study, we have shown that FADD has multiple functions in Xenopus embryos; it plays roles in heart formation as well as apoptosis. We also established a transgenic frog line expressing a biosensor, which is suitable for detecting dying cells, and observed the change of the biosensor in developing embryos when apoptosis was induced
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
細胞死誘導アダプター分子FADDの胚発生における機能解析
细胞死亡诱导衔接分子FADD在胚胎发育中的功能分析
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[酒巻和弘, 高木知世, 木村春奈, 鄭祥基, 大川克也, 上野直人]
通讯作者:
上野直人
Study for the cell lineage and tissue specificity in embryonic cells using transgenic Xenopus frogs
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批准号:17570176
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2005
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负责人:SAKAMAKI Kazuhiro
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依托单位:
Analysis of the structure and interaction of apoptotic signaling molecules via Fas
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批准号:10680606
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:1998
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负责人:SAKAMAKI Kazuhiro
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依托单位:
海外基金