Molecular and Cellular mechanisms of germline mother cell regeneration in colonial tunicates

被囊动物种系母细胞再生的分子和细胞机制

• 批准号: 21570227
• 负责人: KAWAMURA Kazuo
• 金额: $ 2.83万
• 依托单位: Kochi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21570227/
• 关键词: 幹細胞; 生殖細胞; 再生; 無性生殖; ホヤ; 生殖系列幹細胞; Vasa; Piwi; Myc; RACK1; 群体ボヤ; NCR; 生殖系列; non-coding RNA; キメラ

Ascidians are the marine invertebrate that is most closely related to vertebrates. Colonial tunicates propagate by means of both sexual and asexual reproduction, and they can regenerate gonads and germ cells even though gonad components are completely extirpated from the colony. This study has disclosed that Myc/ Piwi-expressing cells are reserved in the hemocoel, and that they respond to BMP to express germline-specific gene Vasa, enabling the regeneration of germline cells and tissues.

海鞘是与脊椎动物关系最密切的海洋无脊椎动物。群体被囊类既可有性繁殖，也可无性繁殖，即使性腺成分从殖民地中完全消失，它们也能再生性腺和生殖细胞。这项研究揭示了Myc/Piwi表达细胞保留在血腔中，并且它们响应BMP表达生殖系特异性基因Vasa，使得生殖系细胞和组织再生。

项目成果

Cellular and molecular basis of germ cell regeneration in colonial tunicates

群体被囊动物生殖细胞再生的细胞和分子基础

• 发表时间: 2009
• 作者: Kawamura;K
• 通讯作者: K

Exploration of origin of germ cells in colonial ascidian, Botryllus primigenus

群体海鞘、Botryllus primigenus 生殖细胞起源的探索

• 发表时间: 2009
• 作者: Sunanaga;T.
• 通讯作者: T.

Cellular and molecular basis of germ cell specification in colonial ascidian, Botryllus primigenus.

群体海鞘、Botryllus primigenus 生殖细胞规范的细胞和分子基础。

• 发表时间: 2010
• 作者: Kashiwase;Y.;Tashiro;M.;Kawamura;K.;Sunanaga;T.
• 通讯作者: T.

Germline cell formation and gonad regeneration in solitary and colonial ascidians.

孤立和群体海鞘的生殖细胞形成和性腺再生。

• DOI: 10.1002/dvdy.22542
• 发表时间: 2011
• 期刊: Developmental dynamics : an official publication of the American Association of Anatomists
• 作者: Kawamura,Kaz;Tiozzo,Stefano;Manni,Lucia;Sunanaga,Takeshi;Burighel,Paolo;DeTomaso,AnthonyW
• 通讯作者: DeTomaso,AnthonyW

The hemocytes of Polyandrocarpa misakiensis : morphology and immune-related activities

米崎多男果血细胞：形态和免疫相关活性

• 发表时间: 2009
• 期刊: Invert. Surv. J.
• 作者: Ballarin;L. and Kawamura;K
• 通讯作者: K