Functional analysis of GGDEF/EAL proteins that control the stability of small RNA

为了阐明细菌生物膜形成控制的机制，我们分析了细菌中 GGDEF/EAL 蛋白的功能。 GGDEF/EAL蛋白CsrD不参与c-di-GMP代谢，改变每个生长期的活性，并通过调节小RNA的稳定性来控制生物膜的形成。另一方面，YliF（GGDEF蛋白）和YliE（EAL蛋白）通过调节c-di-GMP的合成和降解来控制生物膜的形成。

To elucidate the mechanism of bacterial biofilm formation control, we analyzed the function of the GGDEF/EAL proteins in bacteria. GGDEF/EAL protein CsrD was not involved in c-di-GMP metabolism and altered the activity in each growth phase and controlled biofilm formation by regulating the stability of small RNA. On the other hand, YliF(GGDEF protein) and YliE(EAL protein) controlled biofilm formation by regulating the synthesis and degradation of c-di-GMP.