Studies on gastrointestinal mucosa-maintaining factors produced during digestion of foods

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Studies on gastrointestinal mucosa-maintaining factors in foods and digested foods were conducted. We found that phosphatidic acid(PA), a characteristic phospholipid in plant foodstuffs, effectively ameliorates aspirin-induced stomach ulcer. The lysophosphatidic acid produced by the hydrolysis of the PA was involved in the ulcer-ameliorating activity of PA. We also identified phytoceramide-1-phsphate as a novel sphingophospholipid with anti-apoptotic activity in cabbage leaves.