Effect of lipid peroxidation on allergic reaction

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Effect of lipid hydroperoxides which could be physiologically produced by reactive oxygen species on allergy reaction was investigated by using cultured cells in vitro. Mast cell line, a kind of white blood cell associated with allergy reaction was cultured and stimulated artificially. The chemical mediators such as histamine released from mast cells were facilitated by 4-hydroxy-2-nonenal, a decomposed product from lipid hydroperoxides. It suggests that lipid peroxidation might deteriorate allergy.