Studies on mechanisms for the crosslinking formation in fish collagen-Cause investigation of the chemical instability in fish collagen

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The chemical instability of fish collagen, higher solubility to dilute acetic acid, indicates that the intermolecular cross-links in fish collagen differ from those in mammal collagen in quantity and/or quality. In fish, however, little information is available on the collagen cross-links, and the mechanism of cross-link formation has not been clear. To obtain the fundamental information on the regulatory mechanism of collagen-cross-linking pathway in fish, the author conducted cDNA cloning of fugu Takifugu rubripes LHs(LH1, 2a, 2b and 3) and performed expression analysis in the adult tissues and the embryos.