The analysis of the cause gene in cattle with growth retardation and establishment of the gene diagnostic method

牛生长迟缓病因基因分析及基因诊断方法的建立

• 批准号: 21580388
• 负责人: OHBA Yasunori
• 金额: $ 3.08万
• 依托单位: Gifu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21580388/
• 关键词: 牛; 発育不良; 遺伝子

It was suggested by analysis using the microsatellite DNA marker that the cause gene of growth retardation in cattle was, not only one, plural genes. As a result of micro-array analysis and real-time PCR, genetic expression to be related to lipid metabolism, cholesterol metabolism, and steroid metabolism significantly rose more than double in cattle with growth retardation in comparison with a normal. It was suggested that growth retardation in cattle is related with these genes.

通过微卫星DNA标记分析表明，牛生长迟缓的原因基因不仅仅是一个，而是多个基因。微阵列分析和实时PCR的结果表明，与正常牛相比，生长迟缓的牛中与脂质代谢、胆固醇代谢和类固醇代谢相关的基因表达显着升高一倍以上。有人认为牛的生长迟缓与这些基因有关。