Effects of the halogenated derivatives of polycyclic aromatic hydrocarbons on gene expression

多环芳烃（PAHs）是一种普遍存在的环境污染物，是由有机化合物不完全燃烧形成的。最近，在环境样品中检测到氯代和溴代多环芳烃。采用实时荧光定量PCR技术，研究其对人乳腺癌细胞MCF7和MDA-MB-231基因表达的影响。PCR结果显示，卤代多环芳烃中多个基因的表达水平与亲本化合物不同。此外，两种细胞系的结果也不同。

Polycyclic aromatic hydrocarbons(PAHs) are ubiquitous environmental contaminants that are formed by the incomplete combustion of organic compounds. Recently, chlorinated and brominated PAHs were detected in the environmental samples. Then their effects on gene expression were investigated by real-time PCR analysis in human breast carcinoma MCF7 and MDA-MB-231 cells. PCR arrays revealed that the expression levels of several genes in halogenated PAHs were different from that in parent compounds. In addition, the different results were obtained between both cell lines.