P2X7 receptor-mediated crosstalk between neurons and astrocytes under resting and stress-loaded conditions

从具有极端攻击性的SJL-小鼠获得的培养星形胶质细胞表达的P2 X7受体被组成性激活，并且活性高于没有攻击性特征的ddY小鼠的情况。这种差异被证明是由于，至少部分是由于P2 X7受体剪接变体的不同表达谱。在应激负荷的星形胶质细胞中，除了P2 X7受体和核苷转运蛋白的功能表达的改变之外，还存在锌的释放，由此通过ATP释放和P2 X7受体的自分泌/旁分泌激活来激活小胶质细胞。这些发现表明P2 X7受体在神经元和神经胶质细胞之间的串扰中起重要作用。

P2X7 receptors expressed by cultured astrocytes obtained from SJL-mice, which is characterized by extreme aggression, were constitutively activated, and the activity was higher than the case of ddY mice, which have no aggression characteristics. This difference was demonstrated to be due, at least in part, to different expression profiles of P2X7 receptor splice variants. In stress-loaded astrocytes, in addition to alteration in functional expression of P2X7 receptors and nucleoside transporters, there was release of zinc, by which microglia was activated via ATP release and autocrine/paracrine activation of P2X7 receptors. These findings indicate that P2X7 receptors play important roles in crosstalk among neuronal and glial cells.