The role of ketone body-utilization on obesity-induced metabolic syndrome

点击翻译按钮获取中文摘要

In order to clarify the role of ketone body-utilization on metabolic disorders, we investigated obesity-induced alterations in the gene expression levels of the newly ketone body-utilizing enzyme, acetoacetyl-CoA synthetase(AACS), in peripheral tissues or central nerve system. As a result, we found that AACS gene expression was affected by treatment with free fatty acid and isoproterenol in white adipocytes. Moreover, we found the possibility that leptin up-regulates ketone body-utilization in neuro-cells and myocytes via activating the AACS transcription.