Kinetics of Dysglycemia Induced by New Quinolone Antibiotics

新型喹诺酮类抗生素引起的血糖异常的动力学

• 批准号: 21590151
• 负责人: YASUHARA Masato
• 金额: $ 3万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590151/
• 关键词: ニューキノロン系抗菌薬; ガチフロキサシン; シベンゾリン; 血糖値異常; ファーマコキネティックス; ファーマコダイナミックス; ペンタミジン; ファーマコキネティクス; 間接モデル; ファーマコキネテックス; 間モデル; インスリン

Gatifloxacin, a fluoroquinolone antibacterial agent, caused hypoglycemia in rats after i. v. administration by increasing the serum concentration of insulin. At higher serum concentration of gatifloxacin, it promoted histamine release, leading to an increased serum epinephrine concentration and hyperglycemia. Cibenzoline induced a rapid increase in the serum concentration of insulin. As the cibenzoline dose was increased, a greater hypoglycemic effect occurred. The time courses of serum concentrations of cibenzoline, insulin and glucose could be described by the pharmacokinetic and pharmacodynamic model developed.

氟喹诺酮类抗菌药物加替沙星i. V.通过增加胰岛素的血清浓度来施用。在较高的加替沙星血清浓度，它促进组胺释放，导致血清肾上腺素浓度增加和高血糖症。Cibenzoline诱导血清胰岛素浓度迅速增加。随着西苯唑啉剂量的增加，发生更大的降血糖作用。所建立的药代动力学和药效学模型可描述西苯唑啉、胰岛素和葡萄糖血药浓度的时程。

项目成果

Pharmacokinetic monitoring is still required for intravenous busulfan in SCT for small children

幼儿SCT中静脉注射白消安仍需进行药代动力学监测

• 发表时间: 2010
• 期刊: International Journal of Hematology 91
• 作者: Masayuki Nagasawa;Noriko Mitsuiki;Toshiaki Ono;Masatoshi Takagi;Hiromi Oda;Masato Yasuhara;Shuki Mizutani
• 通讯作者: Shuki Mizutani

Pharmacodynamics of Cibenzoline-Induced Hypoglycemia in Rats

• DOI: 10.2133/dmpk.dmpk-10-rg-127
• 发表时间: 2011-01-01
• 期刊: DRUG METABOLISM AND PHARMACOKINETICS
• 影响因子: 2.1
• 作者: Takahashi, Yutaka;Ishiwata, Yasuyoshi;Yasuhara, Masato
• 通讯作者: Yasuhara, Masato

Concurrent administration of intravenous systemic and intravitreal methotrexate for intraocular lymphoma with central nervous system involvement

• DOI: 10.1007/s12185-010-0589-6
• 发表时间: 2010-07-01
• 期刊: INTERNATIONAL JOURNAL OF HEMATOLOGY
• 影响因子: 2.1
• 作者: Nakauchi, Yusuke;Takase, Hiroshi;Arai, Ayako
• 通讯作者: Arai, Ayako

Pharma-codynamics of gatifloxacininduced dysglycemia in rats

加替沙星致大鼠血糖异常的药效学

• 发表时间: 2010
• 作者: M. Yasuhara;Y. Ishiwata
• 通讯作者: Y. Ishiwata

Deficiency of Chemokine Receptor CCR1 Causes Osteopenia Due to Impaired Functions of Osteoclasts and Osteoblasts

• DOI: 10.1074/jbc.m109.099424
• 发表时间: 2010-09-10
• 期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
• 影响因子: 4.8
• 作者: Hoshino, Akiyoshi;Iimura, Tadahiro;Yamamoto, Kenji
• 通讯作者: Yamamoto, Kenji