Kinetics of Dysglycemia Induced by New Quinolone Antibiotics

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Gatifloxacin, a fluoroquinolone antibacterial agent, caused hypoglycemia in rats after i. v. administration by increasing the serum concentration of insulin. At higher serum concentration of gatifloxacin, it promoted histamine release, leading to an increased serum epinephrine concentration and hyperglycemia. Cibenzoline induced a rapid increase in the serum concentration of insulin. As the cibenzoline dose was increased, a greater hypoglycemic effect occurred. The time courses of serum concentrations of cibenzoline, insulin and glucose could be described by the pharmacokinetic and pharmacodynamic model developed.