Effect of the intake of grapefruit juice on blood pressures in hypertensive patients treated with calcium channel blockers

摄入柚子汁对接受钙通道阻滞剂治疗的高血压患者血压的影响

• 批准号: 21590171
• 负责人: UCHIDA Shinya
• 金额: $ 2.91万
• 依托单位: University of Shizuoka
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590171/
• 关键词: 臨床薬学; 相互作用; 臨床効果; グレープフルーツジュース; カルシウム拮抗薬; 薬物相互作用; 血漿中濃度; 健康食品; 降圧薬; 臨床試験

Grapefruit juice(GFJ) was reported to increase the concentration of calcium channel(Ca) blockers by inhibiting cytochrome P450(CYP) 3A4.The aim of this study was to clarify effect of the intake of GFJ on blood pressures in hypertensive patients treated with Ca blockers, amlodipine and nifedipine. Five Japanese patients consumed GFJ and water in 2-way crossover trial. Home blood pressures were measured by electrical devices. There was no significant difference of blood pressure of patients between GFJ phase and water phase(126/82 mmHg in GFJ phase vs 126/80 mmHg in water phase). In conclusion, there might be little impact of the intake of GFJ on blood pressure in hypertensive patients.

据报道，葡萄柚汁（GFJ）通过抑制细胞色素P450(CYP) 3A4来增加钙通道（Ca）阻滞剂的浓度。本研究的目的是阐明摄入GFJ对钙受体阻滞剂、氨氯地平和硝苯地平治疗的高血压患者血压的影响。在双交叉试验中，5名日本患者服用GFJ和水。家用电器测量血压。GFJ期和水期患者血压无显著差异（GFJ期126/82 mmHg vs水期126/80 mmHg）。综上所述，摄入GFJ对高血压患者血压的影响可能不大。

项目成果

ミダゾラム及びその代謝物の尿中排泄量を用いたCYP3A4活性評価

利用咪达唑仑及其代谢物的尿排泄评价 CYP3A4 活性

• 发表时间: 2009
• 作者: 内田信也;三浦基靖;三坂眞元;加藤安宏;山田静雄;大橋京一;渡邉裕司;並木徳之
• 通讯作者: 並木徳之

薬物相互作用検出のためのin vivoでのラットおよび健常人対象試験

药物相互作用检测的大鼠和健康人体体内研究

• 发表时间: 2011
• 作者: 内田信也;田中紫茉子;乾直輝;竹内和彦;渡邉裕司;大橋京一;並木徳之
• 通讯作者: 並木徳之

ミダゾラム及び代謝物の尿中排泄量と血漿中濃度時間曲線下面積との関係

咪达唑仑尿排泄量及其代谢物与血药浓度时间曲线下面积的关系

• 发表时间: 2010
• 作者: 三浦基靖;内田信也;三坂眞元;加藤安宏;山田静雄;大橋京一;渡邉裕司;並木徳之
• 通讯作者: 並木徳之

Pharmacokinetics and pharmacodynamics of midazolam administered intravenously and orally at low doses to healthy volunteers

健康志愿者低剂量静脉注射和口服咪达唑仑的药代动力学和药效学

• 发表时间: 2010
• 期刊: Clin. Exp. Pharmacol. Physiol
• 作者: Shingen Misaka;Shinya Uchida;Hiromitsu Imai;Naoki Inui;Shinichiro Nishio;Kyoichi Ohashi;Hiroshi Watanabe;Shizuo Yamada
• 通讯作者: Shizuo Yamada

In-vivo phenotyping for CYP3A4 by determination of a single-point plasma concentration and urinary excretion of midazolam and its metabolites

通过测定咪达唑仑及其代谢物的单点血浆浓度和尿排泄来对 CYP3A4 进行体内表型分析

• 发表时间: 2010
• 作者: Shinya Uchida;Motoyasu Miura;Shingen Misaka;Yasuhiro Katoh;Shizuo Yamada;Kyoichi Ohashi;Hiroshi Watanabe;Noriyuki Namiki
• 通讯作者: Noriyuki Namiki