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Molecular basis of epigenetics on the mechanisms of sex determination and its failure

Molecular basis of epigenetics on the mechanisms of sex determination and its failure
表观遗传学关于性别决定及其失败机制的分子基础
批准号:
21590357
负责人:
HOSHI Nobuhiko
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
Testis development in mammals begins with the activation of Y-linked Sry gene, which triggers a cascade of events that lead to male pathway. To clarify the regulation mechanism of testis differentiation, we investigated the epigenetic change of the gonadal development of a unique mouse carrying Y^<pos> that showed sex reversal with true hermaphrodites, and clinical case with disorder of sex differentiation(DSD) patient. We showed that the profiles of methylation and acetylation of SRY gene and revealed some of causation of diversity of DSD.
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发表时间: 2009
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大鼠肠上皮细胞凋亡过程的超微结构和免疫组化研究。
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大鼠结肠粘膜上皮Toll样受体的表达和分泌
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发表时间: 2011
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作者: [星野重樹, 他, 万谷洋平,亀崎青沙,Udayanga Kankanam Gamage Sanath,高原英一郎,谷田任司,河野潤一,横山俊史,星 信彦,北川 浩]
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发表时间: 2011
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影响因子: 2
作者: [Mantani, Y., Kamezaki, A., Udayanga, K. G. S., Takahara, E., Qi, W.-M., Yokoyama, T., Kawano, J., Hoshi, N., Kitagawa, H.]
通讯作者: H.
95
    Elucidation of mechanisms on the sex differentiation gene family and its mutual regulation
    Effects of fetal and neonatal exposure of male mice to diethylstilbestrol as endocrine disrupter on the reproductive and neuroendocrine system
    • 批准号:
      12836014
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.05万
    • 财政年份:
      2000
    • 负责人:
      HOSHI Nobuhiko
    • 依托单位:
    Study on the sex differentiation relation genes and their mutual regulation
    Molecular genetic study on sex determination, differentiation and sexual differentiation anomaly.
    • 批准号:
      08671858
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.41万
    • 财政年份:
      1996
    • 负责人:
      HOSHI Nobuhiko
    • 依托单位:
    海外基金