Molecular basis of epigenetics on the mechanisms of sex determination and its failure
Molecular basis of epigenetics on the mechanisms of sex determination and its failure
批准号:
21590357
负责人:
HOSHI Nobuhiko
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
点击翻译按钮获取中文摘要
英文摘要
Testis development in mammals begins with the activation of Y-linked Sry gene, which triggers a cascade of events that lead to male pathway. To clarify the regulation mechanism of testis differentiation, we investigated the epigenetic change of the gonadal development of a unique mouse carrying Y^<pos> that showed sex reversal with true hermaphrodites, and clinical case with disorder of sex differentiation(DSD) patient. We showed that the profiles of methylation and acetylation of SRY gene and revealed some of causation of diversity of DSD.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
ラット腸管の濾胞被蓋上皮における上皮細胞の動態に関する計量免疫組織化学的研究
大鼠肠道滤泡被盖上皮上皮细胞动力学的定量免疫组织化学研究
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Onishi, S., et. al., 万谷洋平(代表), Kankanam Gamage Sanath UDAYANGA (代表), 西田美穂(代表), 伊藤栄理(代表), Kankanam Gamage Sanath UDAYANGA (代表), 伊藤栄理(代表), 宮田英典(代表)]
通讯作者:
宮田英典(代表)
Ultrastructural and immunohistochemical study on the apoptotic process of intestinal epithelial cells in rats.
大鼠肠上皮细胞凋亡过程的超微结构和免疫组化研究。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Miho NISHIDA, et al.]
通讯作者:
et al.
ラットの大腸粘膜上皮におけるToll-like receptorの発現と分泌
大鼠结肠粘膜上皮Toll样受体的表达和分泌
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[星野重樹, 他, 万谷洋平,亀崎青沙,Udayanga Kankanam Gamage Sanath,高原英一郎,谷田任司,河野潤一,横山俊史,星 信彦,北川 浩]
通讯作者:
万谷洋平,亀崎青沙,Udayanga Kankanam Gamage Sanath,高原英一郎,谷田任司,河野潤一,横山俊史,星 信彦,北川 浩
Site differences of the Toll-like receptor expression in the mucous epithelium of rat small intestine
大鼠小肠粘膜上皮Toll样受体表达位点差异
DOI:
--
发表时间:
2011
期刊:
Histology and Histopathology
影响因子:
2
作者:
[Mantani, Y., Kamezaki, A., Udayanga, K. G. S., Takahara, E., Qi, W.-M., Yokoyama, T., Kawano, J., Hoshi, N., Kitagawa, H.]
通讯作者:
H.
DOI:
10.14670/hh-26.811
发表时间:
2011-07-01
期刊:
HISTOLOGY AND HISTOPATHOLOGY
影响因子:
2
作者:
[Udayanga, K. G. S., Miyata, H., Kitagawa, H.]
通讯作者:
Kitagawa, H.
共 95 条
Elucidation of mechanisms on the sex differentiation gene family and its mutual regulation
-
批准号:15390510
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.62万
-
财政年份:2003
-
负责人:HOSHI Nobuhiko
-
依托单位:
Effects of fetal and neonatal exposure of male mice to diethylstilbestrol as endocrine disrupter on the reproductive and neuroendocrine system
-
批准号:12836014
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.05万
-
财政年份:2000
-
负责人:HOSHI Nobuhiko
-
依托单位:
Study on the sex differentiation relation genes and their mutual regulation
-
批准号:10671509
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.11万
-
财政年份:1998
-
负责人:HOSHI Nobuhiko
-
依托单位:
Molecular genetic study on sex determination, differentiation and sexual differentiation anomaly.
-
批准号:08671858
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.41万
-
财政年份:1996
-
负责人:HOSHI Nobuhiko
-
依托单位:
海外基金