Epigenetic modification of micro RNA expression in serrated polyp-carcinoma pathway

锯齿状息肉癌通路中微小RNA表达的表观遗传修饰

• 批准号: 21590394
• 负责人: MITOMI Hiroyuki
• 金额: $ 3万
• 依托单位: Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590394/
• 关键词: マイクロRNA; 鋸歯状ポリープ; 大腸腫瘍; 遺伝子メチル化; DNAミスマッチ修復遺伝子; 消火器・唾液腺; 大腸癌; micro RNA; Pathched; EphB2; 消化器・唾液腺; 大腸; ポリープ; microRNA

Serrated polyp including sessile and traditional serrated polyp/adenoma is a precursor to a subset of microsatellite-unstable colorectal carcinoma. In contrast, hyperplastic polyp is considered to have very low risk of progression to carcinoma. Histological discrimination is sometimes difficult and problematic between two polyps because of both having architectural similarities. We found a differential expression of microRNA 20, 21, 93 and 181b in serrated and hyperplastic polyps. We have further shown that loss of mismatch repair protein hMLH1 expression, probably as a result of gene methylation, is inversely correlated with microRNA 21 and 93 in serrated polyp. Our results point toward a potential target therapy of these microRNA in serrated polyp development or progression.

锯齿状息肉包括无梗和传统的锯齿状息肉/腺瘤，是微卫星不稳定结直肠癌的前兆。相反，增生性息肉被认为发展为癌的风险很低。组织学区分有时是困难的和有问题的两个息肉，因为两者都有结构上的相似性。我们发现microRNA 20、21、93和181b在锯齿状和增生性息肉中的差异表达。我们进一步发现，在锯齿状息肉中，错配修复蛋白hMLH1表达的缺失（可能是基因甲基化的结果）与microRNA 21和93呈负相关。我们的研究结果指出了这些microRNA在锯齿状息肉发展或进展中的潜在靶向治疗。

项目成果

Predictive value of MGMT, hMLH1, hMSH2 and BRCA1 protein expression for pathological complete response to neoadjuvant chemotherapy in basal-like breast cancer patients

• DOI: 10.1007/s00280-011-1777-7
• 发表时间: 2012-04-01
• 期刊: CANCER CHEMOTHERAPY AND PHARMACOLOGY
• 影响因子: 3
• 作者: Nakai, Katsuya;Mitomi, Hiroyuki;Kasumi, Fujio
• 通讯作者: Kasumi, Fujio

Aberrant p16INK4a methylation is a frequent event in colorectal cancers: prognostic value and relation to mRNA expression and immunoreactivity

• DOI: 10.1007/s00432-009-0688-z
• 发表时间: 2010-02-01
• 期刊: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
• 影响因子: 3.6
• 作者: Mitomi, Hiroyuki;Fukui, Naoshi;Yao, Takashi
• 通讯作者: Yao, Takashi

デスモイド腫瘍におけるβ-cateninの遺伝子異常のタイプと標的遺伝子の活性化能および細胞増殖能の比較検討

硬纤维瘤β-catenin基因异常类型、靶基因激活能力、细胞增殖能力的比较研究

• 发表时间: 2010
• 作者: 齋藤剛;三富弘之;三谷恵子;八尾隆史
• 通讯作者: 八尾隆史

Role for p16INK4a in progression of gastrointestinal stromal tumors of the stomach: alteration of p16INK4a network members

• DOI: 10.1016/j.humpath.2011.01.005
• 发表时间: 2011-10-01
• 期刊: HUMAN PATHOLOGY
• 影响因子: 3.3
• 作者: Mitomi, Hiroyuki;Fukui, Naoshi;Yao, Takashi
• 通讯作者: Yao, Takashi

癌併存大腸広基性鋸歯状腺腫/ポリープの臨床病理学的特徴

结肠巨大锯齿状腺瘤/息肉癌的临床病理特征

• 发表时间: 2011
• 期刊: 胃と腸
• 作者: Hasebe T;et al.;三富弘之,五十嵐誠治,伴慎一,九嶋亮治,藤田恒平,平橋美奈子,大城由美,林大久生,八尾隆史
• 通讯作者: 三富弘之,五十嵐誠治,伴慎一,九嶋亮治,藤田恒平,平橋美奈子,大城由美,林大久生,八尾隆史