Basic studies for the immune responses against cancer stem cells of sold tumors

我们研究了癌症干细胞（CSCs）的免疫病理特性，这是一小群具有干细胞样表型和肿瘤启动能力的癌细胞。从各种癌细胞系中收集csc并分析csc特异性基因。三个基因被鉴定为csc特异性抗原的候选基因。我们可以从癌症患者身上诱导csc特异性细胞毒性t细胞（ctl）。在小鼠模型中，过继转移ctl显示出更高的体内肿瘤抑制能力。我们的研究证明了csc靶向免疫治疗的潜力。

We investigated the immunopathological properties of cancer stem cells(CSCs), a small population of cancer cells with stem cell-like phenotype and tumor-initiating capacity. CSCs were collected from various cancer cell lines and analyzed for CSC-specific genes. Three genes were identified as candidates for CSC-specific antigens. We could induce CSC-specific cytotoxic T-cells(CTLs) from cancer patients. Adoptive transfer of the CTLs showed higher tumor suppressive capacity in vivo in a mouse model. Our studies demonstrated a potential of CSC-targeted immunotherapy.