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Roles of SIX3 and SIL in the Hedgehog signaling during pancreatic carcinogenesis.

Roles of SIX3 and SIL in the Hedgehog signaling during pancreatic carcinogenesis.
SIX3 和 SIL 在胰腺癌发生过程中 Hedgehog 信号传导中的作用。
批准号:
21590408
负责人:
KASAI Kenji
金额:
$2.5万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
SIX3 protein was expressed in the normal duct cells of the pancreas whereas not in PanIN/cancer cells. Human SIX3 promoter contained a CpG island which was methylated in SIX3(-) pancreatic cancer cell lines. Reporter assay revealed roles of SIX3 and TLE1/HDAC1 in the MACS1-dependent suppression of human Shh gene. SIL was strongly expressed in PanIN/cancer cells of the pancreas. It was also weakly expressed at the basal of the normal duct cells of the pancreas, indicating its role for the cellular attachment to the matrix.
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会议论文
膵臓癌およびPancreatic Intraepithelial Neoplasia(PanIN)におけるSIL発現状況の免疫組織学的解析
胰腺癌和胰腺上皮内瘤变 (PanIN) 中 SIL 表达状态的免疫组织化学分析
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [米山亜紀子, 稲熊真悟, 笠井謙次, 池田洋]
通讯作者: 池田洋
GLI1 enhances the motility and invasion by gel forming mucin MUC5AC up-regulation in pancreatic cancer cells
GLI1通过凝胶形成粘蛋白MUC5AC上调增强胰腺癌细胞的运动和侵袭
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [吉田功, 宮前結加, 沼田賀子, 鶴田智子, 三上哲夫, 岡安勲, 稲熊真悟]
通讯作者: 稲熊真悟
胃小細胞癌の一例遺伝子変異・LOH解析を含めた検討
胃小细胞癌基因突变及LOH分析一例
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [稲熊真悟, 笠井謙次, 池田洋]
通讯作者: 池田洋
GLI1 facilitates the migarion and invasion of pancreatic cancer cellls through MUC5AC-mediated attenuation of E-cadherin.
GLI1通过MUC5AC介导的E-钙粘蛋白减弱促进胰腺癌细胞的迁移和侵袭。
DOI: --
发表时间: 2011
期刊: Oncogene
影响因子: 8
作者: [S Inaguma, K Kasai, H Ikeda.]
通讯作者: H Ikeda.
11
    Hedgehog signaling molecule SIL regulates the migration and progression of pancreatic ductal adenocarcinoma.
    • 批准号:
      24590456
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.0万
    • 财政年份:
      2012
    • 负责人:
      KASAI Kenji
    • 依托单位:
    Roles of the Hedgehog signaling in invasion and metastasis of pancreatic cancer
    • 批准号:
      19590371
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.83万
    • 财政年份:
      2007
    • 负责人:
      KASAI Kenji
    • 依托单位:
    海外基金