Novel roles of connexin32 in expansion of cancer stem cell population and enhancement of metastasis

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While connexin protein is localised in plasma membrane and functions tumour-suppressively, it often translocates into cytoplasm of cancer cells. In this study, discovering that cytoplasmic accumulation of connexin enhanced self-renewal of cancer stem cells, we successfully proved that an increased number of cancer stem cells elevated the incidence of cancer metastasis. It is strongly expected that cancer metastasis could be controlled by manipulating subcellular localisation of connexin.