Development of efficient bone marrow transplantation and its application for treatment of malignant tumor or regeneration therapy

骨髓内-骨髓移植（IBM-BMT）是一种较传统的静脉骨髓移植（BMT）更为有效的骨髓移植方法。在这项研究中，我们使用磁珠和磁铁的IBM-BMT。首先，我们用磁珠包被供体骨髓细胞（BMC）。接下来，我们将供体的BMCs移植到受体的胫骨骨髓中。当供体骨髓基质细胞被注射到骨中时，一个强大的磁铁被环绕在骨周围。带有磁珠和磁铁的IBM-BMT显示供体BMC快速造血。

Intra-bone marrow-bone-marrow transplantation(IBM-BMT) is more efficientmethod for bone marrow transplantation than conventionalintra-venous bone marrow transplantation(BMT). In this study, we used magnet-beads and a magnet for IBM-BMT. First, we coated donor bone marrow cells(BMCs) with magnet-beads. Next, we transplantedthe donor BMCs into the recipient bone marrow of the tibia. A powerful magnet wascircumferentiallyset around the bone when the donor BMCs were injected into the bone. IBM-BMT with magnet-beads and a magnet showed rapid hematopoiesis of donor BMCs.