Recognition of Candida DNA and regulation of signaling by C type lectin receptor

真菌白色念珠菌在口腔和胃肠道的粘膜组织中定居，是正常共生微生物区系的一部分。然而，在免疫功能受损的情况下，它可能会导致局部和系统性念珠菌病。为了了解宿主对白色念珠菌的防御机制，我们分析了TLR9和Dectin-2之间的信号相互作用，观察到这两种受体协同诱导免疫应答，调节宿主在白色念珠菌感染过程中的免疫状态。

The fungus Candida albicans colonizes the mucosal tissue of the oral cavity and the gastrointestinal tract, where it is part of the normal commensal microflora. However, under immune-compromised conditions, it can cause local and systemic candidiasis. To understand host defense mechanism against Candida, we analysed the interaction of signaling between TLR9 and dectin-2.As a result, we observed the collaborative induction of immune responses by these two receptors, which regulated the immunological status of the host during Candida albicans infection.