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Development of immunotherapy and virotherapy against ATL

Development of immunotherapy and virotherapy against ATL
针对ATL的免疫疗法和病毒疗法的发展
批准号:
21590504
负责人:
OHASHI Takashi
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

项目摘要

项目成果

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中文摘要
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英文摘要
The potential for novel therapies against Human T-cell leukemia virus type I (HTLV-I) induced-adult T-cell leukemia (ATL) has been assessed in a rat model of HTLV-I infection. The results indicate that the single chain trimer (SCT) of MHC-I linked to HTLV-I epitope peptide is able to induce HTLV-I-specific cytotoxic responses and that LC16m8Δ, a highly attenuated vaccinia strain, has an ability to lyse HTLV-I-infected T cells. These results should be useful for further verifying the strategies to fight against HTLV-I.
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DOI: 10.1186/1742-4690-6-43
发表时间: 2009-05-12
期刊: Retrovirology
影响因子: 3.3
作者: [Okada H, Zhang X, Ben Fofana I, Nagai M, Suzuki H, Ohashi T, Shida H]
通讯作者: Shida H
Functional analysis of Foxp3 and CTLA-4 expressing HTLV-1-infected cells in a rat model
大鼠模型中表达 HTLV-1 感染细胞的 Foxp3 和 CTLA-4 的功能分析
DOI: 10.1093/intimm/dxp089
发表时间: 2009
期刊: Microbes Infect
影响因子: 5.8
作者: [Takayanagi R., Ohashi T., and Shida H]
通讯作者: and Shida H
Induction of IL-10- and IFN-γ-producing T-cell responses by autoreactive T-cells expressing human T-cell leukemia virus type I Tax.
通过表达人 T 细胞白血病病毒 I 型 Tax 的自身反应性 T 细胞诱导产生 IL-10 和 IFN-γ 的 T 细胞应答。
DOI: --
发表时间: 2009
期刊: Int Immunol. 21
影响因子: --
作者: [Takatsuka N, Hasegawa A, Takamori A, Shimizu Y, Kato H, Ohashi T, Amagasa T, Masuda T, Kannagi M.]
通讯作者: Kannagi M.
Inhibitory effect of human TRIM5alpha on HIV-1 production.
人 TRIM5alpha 对 HIV-1 产生的抑制作用。
DOI: --
发表时间: 2010
期刊: Microbes Infect.
影响因子: --
作者: [Shanshuang Li, Robert Leo Skov, Xiao Han, Anders Rhod Larsen, Jesper Larsen, Marit Sorum, Mireille Wulf, Andreas Voss, Keiichi Hiramatsu, Teruyo Ito, Zhang X.]
通讯作者: Zhang X.
6
    Development of HTLV-I-specific anti-cancer therapy by using single chain T cell receptors and single chain trimers of MHC-I.
    • 批准号:
      24590547
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.41万
    • 财政年份:
      2012
    • 负责人:
      OHASHI Takashi
    • 依托单位:
    Analysis of anti-HTLV-I immune response and development of immunotherapy by using single-chain trimers of MHC-I
    • 批准号:
      19590466
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.91万
    • 财政年份:
      2007
    • 负责人:
      OHASHI Takashi
    • 依托单位:
    Establishment of an HTLV-I infection model by using human CRM1-transgenic rats
    • 批准号:
      17590411
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.3万
    • 财政年份:
      2005
    • 负责人:
      OHASHI Takashi
    • 依托单位:
    Functional analysis of HTLV-I Tax in vivo using a rat model system
    海外基金