Development of immunotherapy and virotherapy against ATL
Development of immunotherapy and virotherapy against ATL
批准号:
21590504
负责人:
OHASHI Takashi
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
The potential for novel therapies against Human T-cell leukemia virus type I (HTLV-I) induced-adult T-cell leukemia (ATL) has been assessed in a rat model of HTLV-I infection. The results indicate that the single chain trimer (SCT) of MHC-I linked to HTLV-I epitope peptide is able to induce HTLV-I-specific cytotoxic responses and that LC16m8Δ, a highly attenuated vaccinia strain, has an ability to lyse HTLV-I-infected T cells. These results should be useful for further verifying the strategies to fight against HTLV-I.
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DOI:
10.1186/1742-4690-6-43
发表时间:
2009-05-12
期刊:
Retrovirology
影响因子:
3.3
作者:
[Okada H, Zhang X, Ben Fofana I, Nagai M, Suzuki H, Ohashi T, Shida H]
通讯作者:
Shida H
Functional analysis of Foxp3 and CTLA-4 expressing HTLV-1-infected cells in a rat model
大鼠模型中表达 HTLV-1 感染细胞的 Foxp3 和 CTLA-4 的功能分析
DOI:
10.1093/intimm/dxp089
发表时间:
2009
期刊:
Microbes Infect
影响因子:
5.8
作者:
[Takayanagi R., Ohashi T., and Shida H]
通讯作者:
and Shida H
Induction of IL-10- and IFN-γ-producing T-cell responses by autoreactive T-cells expressing human T-cell leukemia virus type I Tax.
通过表达人 T 细胞白血病病毒 I 型 Tax 的自身反应性 T 细胞诱导产生 IL-10 和 IFN-γ 的 T 细胞应答。
DOI:
--
发表时间:
2009
期刊:
Int Immunol. 21
影响因子:
--
作者:
[Takatsuka N, Hasegawa A, Takamori A, Shimizu Y, Kato H, Ohashi T, Amagasa T, Masuda T, Kannagi M.]
通讯作者:
Kannagi M.
Inhibitory effect of human TRIM5alpha on HIV-1 production.
人 TRIM5alpha 对 HIV-1 产生的抑制作用。
DOI:
--
发表时间:
2010
期刊:
Microbes Infect.
影响因子:
--
作者:
[Shanshuang Li, Robert Leo Skov, Xiao Han, Anders Rhod Larsen, Jesper Larsen, Marit Sorum, Mireille Wulf, Andreas Voss, Keiichi Hiramatsu, Teruyo Ito, Zhang X.]
通讯作者:
Zhang X.
Induction of IL-10-and IFN-g-producing T-cell responses by autoreactive T-cells expressing human T-cell leukemia virus type I Tax
表达人 T 细胞白血病病毒 I 型的自身反应性 T 细胞诱导产生 IL-10 和 IFN-g 的 T 细胞应答
DOI:
--
发表时间:
2009
期刊:
Int.Immunol. 21
影响因子:
--
作者:
[N.Takatsuka, A.Hasegawa, A.Takamori, Y.Shimizu, H.Kato, T.Ohashi, T.Amagasa, T.Masuda, M.Kannagi]
通讯作者:
M.Kannagi
共 6 条
Development of HTLV-I-specific anti-cancer therapy by using single chain T cell receptors and single chain trimers of MHC-I.
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批准号:24590547
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.41万
-
财政年份:2012
-
负责人:OHASHI Takashi
-
依托单位:
Analysis of anti-HTLV-I immune response and development of immunotherapy by using single-chain trimers of MHC-I
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批准号:19590466
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
-
财政年份:2007
-
负责人:OHASHI Takashi
-
依托单位:
Establishment of an HTLV-I infection model by using human CRM1-transgenic rats
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批准号:17590411
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
-
财政年份:2005
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负责人:OHASHI Takashi
-
依托单位:
Functional analysis of HTLV-I Tax in vivo using a rat model system
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批准号:15590413
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.3万
-
财政年份:2003
-
负责人:OHASHI Takashi
-
依托单位:
海外基金