Identification and functional analysis of anti-HIV host factor in macrophages

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Recently, it has been reported that there are an anti-HIV host factors which inhibit reverse transcription of the viral genome macrophages-specifically, as a target factors of HIV-2 Vpx protein. In this study, preparation for identification of these host factors had been performed. However, in 2011, SAMHD1and APOBEC3A were identified as these factors, and almost all functional details of these proteins have been revealed. Thus, in this study, roles of C-terminal polyproline motif(PPM) have been examined. As a result, we suggested that PPM suppresses lysosomal degradation and proteasome degradation of Vpx protein.