Study on early diagnosis of hypercoagulable state and mechanism for the onset in thrombosis

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Elevated hemostatic molecular markers and decreased anticoagulant factors are observed in the onset of thrombosis, thus suggesting that these markers are useful for both making diagnosis of thrombosis and predicting the outcome or efficacy of treatment. Not only hereditary deficiencies of anticoagulant factor such as protein S Tokushima but also secondary deficiencies of anticoagulant factor are frequently observed in the patients with thrombosis. Data from the monitoring of anticoagulant therapy suggest that elevated fibrinolysis may be more important than the anti-Xa activity for assessing major bleeding.