Effects of mild hypoxia on the restoration in cerebral blood flow during temporal decreases in blood pressure and dynamic cerebral autoregulation.

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We conducted this study estimating the restoration rate in cerebral blood flow during temporal decreases in blood pressure, to test our hypothesis that dynamic cerebral autoregulation is impaired during acute exposure to mild hypoxia. The percentage restoration in CBF velocity by thigh cuff deflation decreased significantly during hypoxia Moreover, transfer function coherence and gain in the very-low-frequency range increased significantly. These results provide together a consistent finding that mild hypoxia impairs dynamic cerebral autoregulation, suggesting high risk of syncope at upright posture during mild hypoxia.