Effects of mild hypoxia on the restoration in cerebral blood flow during temporal decreases in blood pressure and dynamic cerebral autoregulation.

轻度缺氧对血压暂时降低期间脑血流恢复和动态脑自动调节的影响。

• 批准号: 21590667
• 负责人: IWASAKI Kenichi
• 金额: $ 1.66万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590667/
• 关键词: 環境; 生理学; 脳血流自動調節; 低酸素; 失神

We conducted this study estimating the restoration rate in cerebral blood flow during temporal decreases in blood pressure, to test our hypothesis that dynamic cerebral autoregulation is impaired during acute exposure to mild hypoxia. The percentage restoration in CBF velocity by thigh cuff deflation decreased significantly during hypoxia Moreover, transfer function coherence and gain in the very-low-frequency range increased significantly. These results provide together a consistent finding that mild hypoxia impairs dynamic cerebral autoregulation, suggesting high risk of syncope at upright posture during mild hypoxia.

我们进行了这项研究，估计在血压短暂下降期间脑血流的恢复率，以验证我们的假设，即急性暴露于轻度缺氧时，动态脑自动调节受到损害。低氧状态下，股袖放气恢复CBF血流速度的百分比显著降低，传递函数相干性和甚低频增益显著增加。这些结果共同提供了一个一致的发现，即轻度缺氧损害了动态的大脑自我调节，表明在轻度缺氧期间，直立姿势晕厥的风险很高。

项目成果

軽度低酸素環境曝露による脳血流自動調節の減弱

轻度缺氧环境导致脑血流自动调节减弱

• 发表时间: 2012
• 期刊: 日本衛生学雑誌
• 作者: 岩崎 賢一;他
• 通讯作者: 他

低酸素血症は脳血流を一定に保つ動きを減弱させる

低氧血症会降低维持恒定脑血流量的能力

• 发表时间: 2012
• 作者: 曷川元;小川洋二郎;青木健;柳田亮;岩崎賢一
• 通讯作者: 岩崎賢一