Studies on involvement of oxidative stresses in pathophysiological investigation of sleep apnea syndrome

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4-Hydroxynonenal(HNE) is an useful marker for oxidative stress. We have developed a highly sensitive method to quantify HNE using time-resolved fluoroimmunoassay. By the method, we found higher serum HNE levels in the patients of sleep apnea syndrome(SAS) compared to the healthy control, in young, middle-aged and elderly groups. We also developed an apparatus in which rats are exposed to intermittent hypoxia by use of nitrogen gas generator. The rats underwent IH showed right ventricular hypertrophy and pulmonary hypertension which are pathognomonic for SAS. Serum HNE was increased in the "IH" rats. These observations suggest that HNE and oxidative stress contribute to the pathogenesis of SAS.