The clinical significance of chronic kidney disease and its biomarker in the oldest old

为了研究慢性肾脏病（CKD）及其生物标志物在老年人中的临床意义，我们建立了一个由542名85岁或以上的社区生活老年人组成的队列。在横断面分析中，我们发现基于肌酐或胱抑素C的肾小球滤过率（eGFR）估计值与微量白蛋白尿、贫血和甲状旁腺激素相关;然而，只有基于胱抑素C的eGFR与颈动脉斑块相关，这表明胱抑素C在检测该人群中心血管疾病高危人群中的有用性。

To examine the clinical implication of chronic kidney disease(CKD) and its biomarker in the older adults, we established a cohort of 542 community-living seniors aged 85 years or older. In the cross-sectional analysis, we found that estimated gulomerular filtration ratios(eGFR) based on creatinine or cystatin C were associated with micro albuminuria, anemia, and parathyroid hormone ; however, only eGFR based on cystatin C was associated with carotid plaque, suggesting usefulness of cystatin C in detecting individuals at high risk for acardiovascular disease in this population.