Elucidation of the cellular transport system of immune-complex via the IgG-Fc receptor and its immune regulation mechanism

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In this study, I examined how FcγR and FcRn expressing on antigen presenting cells existing in the mucous membrane were concerned with the antigen presenting functions from the uptake of the antigen-IgG complex. As a result, the antigen-IgG complex was taken through FcγR in cell surface, and then was disintegrated in endosome, followed by being combined with FcRn. In addition, this study revealed the possibility that the antigen presenting ability was decreased by a loss of the FcRn functions. Therefore, the transport of IgG and the antigen-IgG complex, and FcγR expressing on antigen presenting cells existing in the mucous membrane may be associated with responsive mechanisms and mucous membrane immunoresponse of the host against the pathogenic microbes.