Elucidation of the cellular transport system of immune-complex via the IgG-Fc receptor and its immune regulation mechanism

在这项研究中，我研究了存在于粘膜的抗原提呈细胞上的FcγR和FcRn表达如何与抗原- igg复合物摄取的抗原提呈功能有关。结果，抗原- igg复合物通过细胞表面的FcγR被摄取，然后在核内体中分解，然后与FcRn结合。此外，本研究还揭示了FcRn功能缺失导致抗原呈递能力下降的可能性。因此，IgG和抗原-IgG复合物的转运以及FcγR在存在于粘膜的抗原呈递细胞上的表达可能与宿主对病原微生物的应答机制和粘膜免疫应答有关。

In this study, I examined how FcγR and FcRn expressing on antigen presenting cells existing in the mucous membrane were concerned with the antigen presenting functions from the uptake of the antigen-IgG complex. As a result, the antigen-IgG complex was taken through FcγR in cell surface, and then was disintegrated in endosome, followed by being combined with FcRn. In addition, this study revealed the possibility that the antigen presenting ability was decreased by a loss of the FcRn functions. Therefore, the transport of IgG and the antigen-IgG complex, and FcγR expressing on antigen presenting cells existing in the mucous membrane may be associated with responsive mechanisms and mucous membrane immunoresponse of the host against the pathogenic microbes.