Elucidation of the cellular transport system of immune-complex via the IgG-Fc receptor and its immune regulation mechanism

阐明免疫复合物通过IgG-Fc受体的细胞转运系统及其免疫调节机制

• 批准号: 21590811
• 负责人: YOSHIDA Masaru
• 金额: $ 2.91万
• 依托单位: Kobe University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590811/
• 关键词: FcRn; IgG; 胞内輸送システム; 免疫; 病原微生物; 細胞内輸送システム; IgG-Fc受容体; 樹状細胞

In this study, I examined how FcγR and FcRn expressing on antigen presenting cells existing in the mucous membrane were concerned with the antigen presenting functions from the uptake of the antigen-IgG complex. As a result, the antigen-IgG complex was taken through FcγR in cell surface, and then was disintegrated in endosome, followed by being combined with FcRn. In addition, this study revealed the possibility that the antigen presenting ability was decreased by a loss of the FcRn functions. Therefore, the transport of IgG and the antigen-IgG complex, and FcγR expressing on antigen presenting cells existing in the mucous membrane may be associated with responsive mechanisms and mucous membrane immunoresponse of the host against the pathogenic microbes.

在这项研究中，我研究了粘膜中存在的抗原提呈细胞上表达的Fc-γR和FcRN是如何与摄取抗原-Ig G复合体的抗原提呈功能有关的。其结果是，抗原-免疫球蛋白复合体通过细胞表面的FcγR被带走，然后在内体中解体，然后与FcRN结合。此外，本研究还揭示了FcRN功能丧失导致抗原提呈能力下降的可能性。因此，粘膜中存在的免疫球蛋白及其复合体的转运和FcγR的表达可能与宿主对病原微生物的应答机制和粘膜免疫应答有关。

项目成果

Neonatal Fc receptor for IgG (FcRn) expressed in the gastric epithelium regulates bacterial infection in mice.

• DOI: 10.1038/mi.2011.53
• 发表时间: 2012-01
• 期刊: Mucosal immunology
• 影响因子: 8

An FcRn-dependent role for anti-flagellin immunoglobulin G in pathogenesis of colitis in mice.

• DOI: 10.1053/j.gastro.2009.07.059
• 发表时间: 2009-11
• 期刊: Gastroenterology
• 影响因子: 29.4
• 作者: Kobayashi K;Qiao SW;Yoshida M;Baker K;Lencer WI;Blumberg RS
• 通讯作者: Blumberg RS

消化管免疫機構の制御と破綻

胃肠道免疫系统的调节和破坏

• 发表时间: 2010
• 作者: Kobayashi K;Qiao SW;Yoshida M;Baker K;Lencer WI;Blumberg RS;吉田優
• 通讯作者: 吉田優

The inhibitory effects of intravenous administration of rabbit immunoglobulin G on airway inflammation are dependent upon Fcγreceptor IIb on CD11c(+) dendritic cells in a murine model

小鼠模型中静脉注射兔免疫球蛋白 G 对气道炎症的抑制作用依赖于 CD11c(+) 树突状细胞上的 Fcγ 受体 IIb

• 发表时间: 2010
• 期刊: Clin Exp Immunol
• 影响因子: 4.6
• 作者: Yamamoto M;Kobayashi K;Ishikawa Y;Nakata K;Funada Y;Kotani Y;Masuda A;Takai T;Azuma T;Yoshida M;Nishimura Y.
• 通讯作者: Nishimura Y.

The transfer of maternal antigen-specific IgG regulates the development of allergic airway inflammation early in life in an FcRn-dependent manner.

母体抗原特异性 IgG 的转移以 FcRn 依赖性方式调节生命早期过敏性气道炎症的发展。

• DOI: 10.1016/j.bbrc.2010.03.170
• 发表时间: 2010
• 期刊: Biochemical and biophysical research communications
• 影响因子: 3.1
• 作者: Nakata,Kyosuke;Kobayashi,Kazuyuki;Ishikawa,Yumiko;Yamamoto,Masatsugu;Funada,Yasuhiro;Kotani,Yoshikazu;Blumberg,RichardS;Karasuyama,Hajime;Yoshida,Masaru;Nishimura,Yoshihiro
• 通讯作者: Nishimura,Yoshihiro