Targeting anticancer drug delivery to colon cancer cells using a fucose-bound nanoparticle approach

岩藻糖基转移酶（FUTs）的表达增加在结肠腺癌细胞中很常见5。FUT是通过不同唾液酸化前体的岩藻糖基化加速恶性转化的关键酶，表明结肠腺癌细胞对L-岩藻糖的关键需求。我们开发了L-岩藻糖结合的脂质体作为载体，用于将抗癌药物特异性地递送至这些细胞。我们报告，静脉注射L-岩藻糖结合的脂质体含有顺铂成功地传递到结肠癌细胞，介导有效的肿瘤生长抑制荷瘤小鼠。

Increased expression of fucosyltransferases(FUTs) is common in colic adenocarcinoma cells5. FUTs are key enzymes accelerating malignant transformation through the fucosylation of different sialylated precursors, suggesting a crucial requirement for L-fucose by colic adenocarcinoma cells. We developed L-fucose-bound liposomes as vehicles for delivery of anticancer drugs specifically to these cells. We report that intravenously injected L-fucose-bound liposomes containing Cisplatin were successfully delivered to colic cancer cells, mediating efficient tumour growth inhibition in tumour-bearing mice.