Analyzing the molecular roles of viral proteins determining the efficacy of anti-viral therapy in hepatitis C virus infection.
Analyzing the molecular roles of viral proteins determining the efficacy of anti-viral therapy in hepatitis C virus infection.
批准号:
21590837
负责人:
MAEKAWA Shinya
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
It is known that viral response to the pegylated-interferon plus ribavirin therapy is significantly different depending on the mutational status of core amino acid 70 in chronic hepatitis C virus(HCV) infection. In this study, we tried to clarify the influence of core 70 mutations on the innate immune system as well as viral replication. Moreover, we tried to clarify patients' characteristics depending on the presence of those mutations.
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Extensive analysis of serum cytokines associated to the response in the PEG-IFN+RBV combination therapy in genotype 1b HCV infection.
与 PEG-IFN RBV 联合疗法治疗基因型 1b HCV 感染反应相关的血清细胞因子的广泛分析。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Kazuki Komase, Maekawa S, Enomoto N, et al]
通讯作者:
et al
A new method for induced fit docking (GENIUS) and its application to virtual screening of novel HCV NS3-4A protease inhibitors
诱导拟合对接新方法(GENIUS)及其在新型HCV NS3-4A蛋白酶抑制剂虚拟筛选中的应用
DOI:
10.1016/j.bmc.2011.09.023
发表时间:
2011
期刊:
Bioorganic & Medicinal Chemistry
影响因子:
3.5
作者:
[Takaya D, Sakamoto N, et al.]
通讯作者:
et al.
Analysis of the response to pegylated-interferon plus ribavirin therapy in chronicHCV-1b infection using comprehensive information of viral and host factors
利用病毒和宿主因素的综合信息分析慢性 HCV-1b 感染患者对聚乙二醇干扰素加利巴韦林治疗的反应
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Maekawa S, et al]
通讯作者:
et al
DOI:
10.1007/s12072-011-9306-7
发表时间:
2012-04-01
期刊:
HEPATOLOGY INTERNATIONAL
影响因子:
6.6
作者:
[Shindo, Hiroko, Maekawa, Shinya, Enomoto, Nobuyuki]
通讯作者:
Enomoto, Nobuyuki
DOI:
10.1007/s12072-011-9267-x
发表时间:
2011-09-01
期刊:
HEPATOLOGY INTERNATIONAL
影响因子:
6.6
作者:
[Kadokura, Makoto, Maekawa, Shinya, Enomoto, Nobuyuki]
通讯作者:
Enomoto, Nobuyuki
共 21 条
Development of the treatment strategy for HCV-related diseases using ultra-deep sequencing technology.
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批准号:24590965
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.49万
-
财政年份:2012
-
负责人:MAEKAWA Shinya
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依托单位:
Analyzing the mechanism of replication of hepatitis C virus by NS3 helicase
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批准号:19590756
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
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财政年份:2007
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负责人:MAEKAWA Shinya
-
依托单位:
Analyzing the contribution of intracellular localization of hepatitis C virus replication complex for the drug resistance.
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批准号:17590627
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
-
财政年份:2005
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负责人:MAEKAWA Shinya
-
依托单位:
海外基金