Arrhythmogenic substrate and therapeutic interventions of Tdp induced by class III and IV antiarrhythmic drugs(Tridimentional mapping of the heart)

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A high correlation was found between surface ECG Tp-e(from peak to end interval of T wave) and total left ventricular dispersion. In contrast, pseudo transmural Tp-e correlated with transmural recovery time(RT) dispersion. The shortest RT in the heart roughly corresponded to the peak, as did the longest RT with the end of the T wave on the surface ECG. Pacing treatment was most effective in anthopleurin-A model followed by E-4031, bepridil and amiodarone model. On the other hand, supplemental treatment of potassium showed the greatest therapeutic effect in E-4031 model. Magnesium homogenized the distribution of ventricular repolarization in anthopleurin-A model but not in the other models created by E-4031, bepridil and amiodarone.