Serial changes in platelet activation biomarkers and the effects of anti-platelet therapy in percutaneous coronary intervention

经皮冠状动脉介入治疗中血小板活化生物标志物的系列变化及抗血小板治疗的效果

• 批准号: 21590903
• 负责人: KAIKITA Koichi
• 金额: $ 2.91万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590903/
• 关键词: 循環器・高血圧; 遺伝子; 経皮的冠動脈インターベンション; クロピドグレル; CYP2C19遺伝子多型; VerifyNow system; 冠動脈疾患; Verify Now system; CYP2C19遺伝子

We investigated the effects of CYP2C19 gene variants on platelet function tests and biomarkers of coagulation activation and inflammation in patients undergoing elective percutaneous coronary intervention(PCI). Only on-clopidogrel residual platelet aggregation was associated with the CYP2C19-reduced function allele in patients treated with clopidgrel. These platelet function tests may be useful for identifying carriers of CYP2C19 reduced-function gene variants and monitoring the efficacy of dual antiplatelet therapy in patients undergoing elective PCI.

我们研究了CYP2C19基因变异对接受择期经皮冠状动脉介入治疗(PCI)患者的血小板功能检测以及凝血激活和炎症生物标志物的影响。在接受氯吡格雷治疗的患者中，只有非氯吡格雷残留的血小板聚集与CYP2C19降低的功能等位基因相关。这些血小板功能检测可能有助于确定CYP2C19功能降低基因变异体的携带者，并监测择期经皮冠状动脉介入治疗患者双重抗血小板治疗的疗效。

项目成果

Functional CYP2C19 Gene Variants are Associated With Both On-clopidogrel Platelet Adhesiveness and Aggregation in Japanese Patients With Coronary Artery Disease

功能性 CYP2C19 基因变异与日本冠状动脉疾病患者的氯吡格雷血小板粘附性和聚集相关

• 发表时间: 2010
• 作者: K Kaikita;T Ono;S Hokimoto;K Tsujita;Y Miyazaki;K Sato;E Horio;H Sumida;S Sugiyama;H Ogawa.
• 通讯作者: H Ogawa.

Impact of CYP2C19 Polymorphism and Diabetes Mellitus on Platelet Reactivity and Clinical Outcomes in Patients Following Coronary Stent Placement

CYP2C19 多态性和糖尿病对冠状动脉支架置入术后患者血小板反应性和临床结果的影响

• 发表时间: 2011
• 作者: Hokimoto S;Mizobe M;Chitose T;Kaikita K;Nakagawa K;Ogawa H
• 通讯作者: Ogawa H

Impact of Proton Pump Inhibitor(PPI) and CYP2C19 Polymorphism on Clinical Outcomes in Acute Coronary Syndrome(ACS) Patients

质子泵抑制剂（PPI）和 CYP2C19 多态性对急性冠状动脉综合征（ACS）患者临床结果的影响

• 发表时间: 2011
• 作者: Hokimoto S;Yamamoto K;Chitose T;OnoT;Kaikita K;Tsujita K;Nakagawa K;Sumida H;Sugiyama S;Ogawa H
• 通讯作者: Ogawa H