A new treatment for arrhythmia with ghrelin via the modulation of autonomic nerve activity

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Male Sprague-Dawley rats were exposed to a 30 minutes of ischemia following ligation of the left coronary artery. Animals were then randomized to receive either ghrelin or saline during the period of coronary ligation. Power spectral analysis of heart rate variability revealed that the administration of ghrelin increased the high-frequency(HF) power and decreased the low-frequency(LF)/ HF ratio. Ventricular tachyarrhythmias were less frequent in rats after MI who received ghrelin in comparison to rats who received saline. Immunoblotting and immunohistovhemistry revealed that rats given saline alone during MI exhibited a marked reduction in phosphorylated connexin 43 within the left ventricle, whereas those that received ghrelin displayed only minor reductions in comparison to sham-operated rats. These effects of ghrelin were diminished by the co-administration of atropine or the blockade of vagal afferents.