Effects of autonomic nervous activity and mechanical stress on the arrhythmogenesis in heart failure

自主神经活动和机械应激对心力衰竭心律失常的影响

• 批准号: 21590920
• 负责人: INAGAKI Masashi
• 金额: $ 2.83万
• 依托单位: National Cardiovascular Center Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590920/
• 关键词: 臨床心血管病態学; 不整脈; 電気生理学

Using optical transmembrane potential mapping, we investigated the spatiotemporal effects of autonomic nerve stimulation and mechanical stress on the electrophysiological characteristics in heart failure rats after myocardial infarction.1) Sympathetic nerve stimulation shortened ventricular action potential duration(APD) in heart failure rats after myocardial infarction. The shortening of APD was larger in the non-infarct area than in the infarct area. As a result, sympathetic nerve stimulation increased inhomogeneity of APD. Vagus nerve stimulation decreased the inhomogeneity of APD.2) The volume pulse applied at the T wave of ECG induced a focal excitation. The focal excitation originated from the surrounding areas of infarction. When the volume pulse was applied after a proper coupling interval, the induced focal excitation developed to ventricular fibrillation.3) Vagus nerve stimulation suppressed electrical remodeling in chronic heart failure.

本研究采用光学跨膜电位标测技术，研究了机械应激和自主神经刺激对心肌梗死后心力衰竭大鼠心室肌电生理特性的时空效应。1）交感神经刺激缩短心肌梗死后心力衰竭大鼠心室动作电位时程（APD）。非梗死区APD缩短大于梗死区。结果，交感神经刺激增加了APD的不均匀性。刺激迷走神经可降低APD的不均匀性。2）在心电图T波处施加容积脉冲可引起局灶性兴奋。局灶性兴奋起源于梗死周围区域。当在适当的耦合间隔后施加容量脉冲时，诱发的局灶性兴奋发展为心室颤动。3）迷走神经刺激抑制慢性心力衰竭的电重构。

项目成果

Macroscopic two-pumptwo-vasculature cardiovascular model to support treatment of acute heart failure.

宏观双泵双血管心血管模型支持急性心力衰竭的治疗。

• 发表时间: 2009
• 作者: Sugimachi M;Sunagawa K;Uemura K;Kamiya A;Shimizu S;Inagaki M;Shishido T.
• 通讯作者: Shishido T.

重回帰分析を用いた致死性不整脈検出アルゴリズムに関する検討

基于多元回归分析的致死性心律失常检测算法研究

• 发表时间: 2010
• 期刊: 生体医工学
• 作者: 阿部誠;テルマ・スガイ・ケイコ;吉澤誠;山家智之;清水一夫;後藤萌;稲垣正司;杉町勝;砂川賢二
• 通讯作者: 砂川賢二

Medetomidine, an alpha2 adrenergic agonist enhances acetylcholine release from cardiac vegal nerve endings through central action

美托咪定是一种 α2 肾上腺素能激动剂，通过中枢作用增强心脏植物神经末梢的乙酰胆碱释放

• 发表时间: 2010
• 作者: S. Shimizu;T. Akiyama;T. Kawada;M. Inagaki;A. Kamiya;T. Shishido;S. Sano;M. Shirai;M. Sugimachi
• 通讯作者: M. Sugimachi

Estimated venous return surface and cardiac output curve precisely predicts new hemodynamics after volume change

估计的静脉回流表面和心输出量曲线精确预测容量变化后的新血流动力学

• 发表时间: 2010
• 作者: Sugimachi M;Sunagawa K;Uemura K;Kamiya A;Shimizu S;Inagaki M;Shishido T
• 通讯作者: Shishido T

Effects of Wall Stress on the Dynamics of Ventricular Fibrillation : A Computer Simulation Study of Mechanoelectric Feedback in "Mechanosensitivity of the Heart"

壁应力对心室颤动动力学的影响：“心脏的机械敏感性”中机械电反馈的计算机模拟研究

• 发表时间: 2009
• 作者: SHirabayashi;M Inagaki;T Hisada;and M Sugimachi
• 通讯作者: and M Sugimachi