Identification and characterization of a novel endoplasmic reticulum molecule involved in cardiomyogenic differentiation and cardiac dysfunction

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We identified PARM-1 as a novel endoplasmic reticulum(ER)-localized protein whose expression was induced by ER stress. In cardiomyocytes, knockdown of PARM-1 increased ER stress-induced apoptosis. In P19CL6 cells, overexpression of PARM-1 increased expression of BMP and phosphorylation of Smad1/5/8, resulting in acceleration of cardiomyogenic differentiation. These results indicate that PARM-1 is an ER-localized protein which plays a protective role against ER stress in postnatal cardiomyocytes, and that PARM-1 promotes cardiomyogenic differentiation through regulating the BMP-Smad signaling pathway.