Indentification of regulatory factors for airway epithelial barrier and study for the role on airway inflammtion

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The airway epithelial barrier provides defenses against inhaled antigens and pathogens, and alterations of epithelial barrier function have been proposed to play a significant role in the pathogenesis of chronic airway diseases. In this study, we demonstrated that EGFR positively regulates permeability barrier development through the Rac1/JNK-dependent pathway. We also found that heregulin activation of ErbB2/ErbB3 heterodimers is essential for the regulation of permeability barrier in the airway epithelial cells. We also found that glucocorticoids have an effects of improving epithelial barrier integrity.