Peptdes and antbodes therapy by acute exacerbaton of idiopathic pumonary fbross-reated autoantgens

特发性肺纤维化(IPF)急性加重期患者细胞凋亡相关自身抗体升高。预后不良的IPF急性加重期患者抗Annexin 1和抗Bax抑制物1抗体升高。预后好的患者抗BID抗体升高。通过ELISPOT分析和细胞内因子分析，自身抗体增强了外周血淋巴细胞的TH2免疫反应，抑制了凋亡细胞的吞噬作用。

Apoptosis-related autoantibodies were elevated in acute exacerbated patients with idiopathic pulmonary fibrosis (IPF). Anti-annexin 1 and anti-Bax inhibitor 1 antibodies were elevated in poor prognosis patients with acute exacerbated IPF. Anti-Bid antibodies were elevated in good prognosis patients. By ELISPOT analysis and intra cytokine assay, autoantibodies enhanced TH2 immune reaction on peripheral lymphocytes and suppressed phagocytosis of apoptotic cells.