The effects of hydrogen gas breathing on the lung injury induced by hyperoxia

氢气呼吸对高氧肺损伤的影响

• 批准号: 21591002
• 负责人: KOBAYASHI Hirosuke
• 金额: $ 3万
• 依托单位: Kitasato University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591002/
• 关键词: 非閉塞性肺疾患癌; 肺線維症; 呼吸器感染症; その他・酸素障害; 酸素障害; 肺障害; 酸素; 活性酸素; 水素; 一酸化窒素; 活性酵素

Survival time of mice exposed to hyperoxia became longer when the mice breathed hydrogen gas, and the leukocytes accumulation in the lungs was reduced. Hydrogen gas protected cultured human alveolar epithelial cells against antimycin A-induced oxidative stress. The level of superoxide produced by mitochondria was significantly low, and the increase in superoxide produced by antimycin A was also lower in the presence of hydrogen gas. Hydrogen gas protected lungs against hyperoxic lung injury.

小鼠呼吸氢气后，高氧暴露小鼠存活时间延长，肺部白细胞积累减少。氢气保护体外培养的人肺泡上皮细胞免受抗霉素a诱导的氧化应激。线粒体产生的超氧化物水平明显较低，抗霉素A在氢气存在下产生的超氧化物增加也较低。氢气保护肺部免受高氧肺损伤。

项目成果

Possible applications of hydrogen gas and nitric oxide for the therapy of critical illness. Invited lecture in the Symposium III : Applications of the Medical Gases NO, CO, H2S and H2 in Critical Illness

氢气和一氧化氮在危重疾病治疗中的可能应用。

• 发表时间: 2011
• 作者: Tomohiro Sawa;Hideshi Ihara and Takaaki Akaike;桑野和善;谷本圭司;Kobayashi H
• 通讯作者: Kobayashi H

Ectopic expression of a T-box transcription factor, eomesodermin, renders CD4+ Th cells cytotoxic by activating both perforin- and FasL-pathways

• DOI: 10.1016/j.imlet.2012.02.013
• 发表时间: 2012-05-30
• 期刊: IMMUNOLOGY LETTERS
• 影响因子: 4.4
• 作者: Eshima, Koji;Chiba, Sayuri;Shinohara, Nobukata
• 通讯作者: Shinohara, Nobukata

Differentiation of side population cells isolated from human amniotic mesenchymal cell into vascular endothelial cells under hypoxic condition

人羊膜间充质细胞侧群细胞缺氧条件下向血管内皮细胞的分化

• 发表时间: 2010
• 作者: Maruyama N;Nishikubo Y;Kokubo K;Shinbo T;Hirose M;Kobayashi M;Sakuragawa N;Kobayashi H
• 通讯作者: Kobayashi H

虚血再潅流障害軽減用治療剤および治療装置

减轻缺血再灌注损伤的治疗剂及装置

• 发表时间: 2010

Respiratory Rhythms in Healthy Subjects and Patients

健康受试者和患者的呼吸节律

• 发表时间: 2010
• 期刊: Advances in Experimental Medicine & Biology
• 作者: Shimane M;Tomita Y;Shinbo T;Kokubo K;Hirose M;Hataishi R;Kubota M;Masuda N;Kobayashi H
• 通讯作者: Kobayashi H