Molecular interaction that is important for the maintenance of glomerular filtration barrier and its significance in the signal transduction system

肾小球滤过屏障功能障碍可引起肾病综合征伴大量蛋白尿。在本研究中，RACK1被鉴定为一种可以与肌动蛋白4相互作用的新分子，肌动蛋白4是维持屏障功能的重要成分。由于已知RACK1与各种信号转导分子相互作用，肌动蛋白4/RACK1相互作用被认为是通过信号转导系统维持屏障功能的重要因素。此外，还报道了肾小球滤过屏障功能障碍的临床病例的新发现。

Dysfunction of the glomerular filtration barrier in the kidney causes nephrotic syndrome with massive proteinuria. In the present study, RACK1 was identified as a novel molecule that can interact with actinin 4, an important component for the maintenance of barrier function. Since RACK1 is known to be interact with various signal transduction molecules, the actinin 4/RACK1 interaction is considered to be important for the maintenance of barrier function via the signal transduction system. In addition, novel findings in clinical cases with dysfunction of the glomerular filtration barrier were reported.