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Identification of quantitative trait loci for diabetic nephropathy in KK-Ay/Ta mice

Identification of quantitative trait loci for diabetic nephropathy in KK-Ay/Ta mice
KK-Ay/Ta 小鼠糖尿病肾病数量性状位点的鉴定
批准号:
21591039
负责人:
TOMINO Yasuhiko
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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TOMINO Yasuhiko的其他基金

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英文摘要
We studied candidate gene loci for diabetic nephropathy using quantitative trait locus(QTL) analysis of KK-Ay/Ta×BALB/cA F2 intercross mice.We examined 270(KK-Ay/Ta×BALB/cA) F2 intercross mice. Genotypes were investigated using microsatellite markers with QTL analysis.ACR in mice at 20 weeks and ACR gain showed a suggestive linkage to chromosome 9. Gene loci contributing to HbA1c indicated a significant linkage to chromosome 7 at 8 and 12 weeks(designed Fbw-1). QTL analysis of KK-Ay/Ta mice revealed several new loci contributing to diabetic nephropathy and related phenotypes. Thus, it appears that type 2 diabetes and nephropathy of KK-Ay/Ta mice have different genetic factors.
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DOI: 10.5301/jn.2011.8433
发表时间: 2012-01-01
期刊: JOURNAL OF NEPHROLOGY
影响因子: 3.4
作者: [Aoki, Tatsuya, Kaneko, Shigeru, Tomino, Yasuhiko]
通讯作者: Tomino, Yasuhiko
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [青木竜弥, 金子滋, 谷本光生, 萩原晋二, 村越真紀, 石川祐史, 豊田一恵, 合田朋仁, 船曳和彦, 堀越哲, 富野康日己]
通讯作者: 富野康日己
2型糖尿病腎症モデルマウス(KK-A^y/Taマウス)におけるQTL解析による腎症疾患感受性遺伝子座の検討
通过QTL分析检测2型糖尿病肾病模型小鼠(KK-A^y/Ta小鼠)肾病疾病易感位点
DOI: --
发表时间: 2010
期刊: 順天堂医学
影响因子: --
作者: [青木竜弥, 谷本光生, 萩原晋二, 村越真紀, 石川祐史, 古川雅子, 合田朋仁, 堀越哲, 富野康日己]
通讯作者: 富野康日己
The role of Th2-dominant mucosal immune responses in glomerular IgA deposition
  • 批准号:
    18590906
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.43万
  • 财政年份:
    2006
  • 负责人:
    TOMINO Yasuhiko
  • 依托单位:
Pathogenesis of glomerulonephritis (IgA nephropathy and FcαR)
  • 批准号:
    11671049
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $1.66万
  • 财政年份:
    1999
  • 负责人:
    TOMINO Yasuhiko
  • 依托单位:
ANALYSIS FOR THE PATHOGENESIS OF IGA NEPHROPATHY
  • 批准号:
    09671176
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $1.47万
  • 财政年份:
    1997
  • 负责人:
    TOMINO Yasuhiko
  • 依托单位: