Identification of quantitative trait loci for diabetic nephropathy in KK-Ay/Ta mice
Identification of quantitative trait loci for diabetic nephropathy in KK-Ay/Ta mice
批准号:
21591039
负责人:
TOMINO Yasuhiko
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
We studied candidate gene loci for diabetic nephropathy using quantitative trait locus(QTL) analysis of KK-Ay/Ta×BALB/cA F2 intercross mice.We examined 270(KK-Ay/Ta×BALB/cA) F2 intercross mice. Genotypes were investigated using microsatellite markers with QTL analysis.ACR in mice at 20 weeks and ACR gain showed a suggestive linkage to chromosome 9. Gene loci contributing to HbA1c indicated a significant linkage to chromosome 7 at 8 and 12 weeks(designed Fbw-1). QTL analysis of KK-Ay/Ta mice revealed several new loci contributing to diabetic nephropathy and related phenotypes. Thus, it appears that type 2 diabetes and nephropathy of KK-Ay/Ta mice have different genetic factors.
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DOI:
10.5301/jn.2011.8433
发表时间:
2012-01-01
期刊:
JOURNAL OF NEPHROLOGY
影响因子:
3.4
作者:
[Aoki, Tatsuya, Kaneko, Shigeru, Tomino, Yasuhiko]
通讯作者:
Tomino, Yasuhiko
2型糖尿病腎症モデルマウスを用いた腎症疾患感受性遺伝子座の検討
2型糖尿病肾病模型小鼠肾病易感位点检测
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[青木竜弥, 金子滋, 谷本光生, 萩原晋二, 村越真紀, 石川祐史, 豊田一恵, 合田朋仁, 船曳和彦, 堀越哲, 富野康日己]
通讯作者:
富野康日己
2型糖尿病腎症モデルマウス(KK-A^y/Taマウス)におけるQTL解析による腎症疾患感受性遺伝子座の検討
通过QTL分析检测2型糖尿病肾病模型小鼠(KK-A^y/Ta小鼠)肾病疾病易感位点
DOI:
--
发表时间:
2010
期刊:
順天堂医学
影响因子:
--
作者:
[青木竜弥, 谷本光生, 萩原晋二, 村越真紀, 石川祐史, 古川雅子, 合田朋仁, 堀越哲, 富野康日己]
通讯作者:
富野康日己
The role of Th2-dominant mucosal immune responses in glomerular IgA deposition
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批准号:18590906
-
项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.43万
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财政年份:2006
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负责人:TOMINO Yasuhiko
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依托单位:
Pathogenesis of glomerulonephritis (IgA nephropathy and FcαR)
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批准号:11671049
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.66万
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财政年份:1999
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负责人:TOMINO Yasuhiko
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依托单位:
ANALYSIS FOR THE PATHOGENESIS OF IGA NEPHROPATHY
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批准号:09671176
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.47万
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财政年份:1997
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负责人:TOMINO Yasuhiko
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依托单位: