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A comprehensive analysis of serine proteases involved in the renal injury induced by aldosterone and salt loading

A comprehensive analysis of serine proteases involved in the renal injury induced by aldosterone and salt loading
醛固酮和盐负荷所致肾损伤中丝氨酸蛋白酶的综合分析
批准号:
21591035
负责人:
KITAMURA Kenichiro
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
翻译
醛固酮在高盐饮食条件下可引起动物严重的器官损伤。我们证明,丝氨酸蛋白酶抑制剂显着降低醛固酮和高盐饮食诱导的肾损伤的进展,表明丝氨酸蛋白酶参与肾损伤的发展。我们分离出纤溶酶作为参与醛固酮诱导的肾损伤的候选丝氨酸蛋白酶。
英文摘要
Aldosterone has been demonstrated to induce severe organ damage to animals when administered with high salt diet. We demonstrated that a serine protease inhibitor significantly reduced the progression of renal injury induced by aldosterone and high salt diet, suggesting that serine proteases are involved in the development of renal injury. We isolated plasmin as a candidate serine protease involved in the aldosterone induced renal injury.
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会议论文
A study of maintenance therapy after intravenous maxacalcitol for secondary hyperparathyroidism
静脉注射马沙骨化醇治疗继发性甲状旁腺功能亢进症后维持治疗的研究
DOI: --
发表时间: 2011
期刊: Clin. Nephrol
影响因子: --
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A Synthetic Serine Protease Inhibitor Camostat Mesilate Inhibited the Proteolytic Activation of gENaC in the Kidney of the Aldosterone-Infused Rats
合成丝氨酸蛋白酶抑制剂甲磺酸卡莫司他抑制醛固酮输注大鼠肾脏中 gENaC 的蛋白水解激活
DOI: --
发表时间: 2011
期刊:
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作者: [Ryuji Morizane, Toshiaki Monkawa, Hiroshi Itoh, K. Uchimura]
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发表时间: 2011
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Regulation of adrenal aldosterone production by serine protease prostasin
丝氨酸蛋白酶前列腺素调节肾上腺醛固酮的产生
DOI: --
发表时间: 2010
期刊: Journal of Biomedicine and Biotechnology 2010
影响因子: --
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14
    Systematic identification of serine proteases involved in the progression of CKD
    Comprehensive analysis of prostasin activators and inhibitors and its application for the elucidation of blood pressure regulation
    • 批准号:
      19590956
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.91万
    • 财政年份:
      2007
    • 负责人:
      KITAMURA Kenichiro
    • 依托单位:
    Prostasin as a diagnositc and therapeutic target for salt-sensitive hypertension
    • 批准号:
      17590834
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.24万
    • 财政年份:
      2005
    • 负责人:
      KITAMURA Kenichiro
    • 依托单位:
    海外基金