Role of bone marrow-derived mononuclear cells on modulation of brain renin-angiotensin system
Role of bone marrow-derived mononuclear cells on modulation of brain renin-angiotensin system
批准号:
21591059
负责人:
YAMAZATO Masanobu
金额:
$2.91万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
We hypothesized that decreased number or function of bone marrow(BM)-derived cells in the brain is related to neurogenic hypertension. Intracerebroventricular(icv) administration of DiI labeled BM-derived cells revealed that a long term attachment of DiI positive cell in the brain. Although icv administration of BM-derived cells did not alter blood pressure in hypertensive rats, higher expression of angiotensin converting enzyme 2(ACE2) and Mn-SOD of the BM-derived cells and its ability to attach in the brain suggest that BM-derived cells may serve as a mobile renin-angiotensin system modulator in the brain.
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Bone marrow derived cells express higher angiotensin-converting enzyme 2(ACE2) and its ability to attach in the brain of hypertensive rats
骨髓来源的细胞表达较高的血管紧张素转换酶2(ACE2)及其在高血压大鼠大脑中的附着能力
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Yamazato M, Ishida A, Yamazato Y, Sakima A, Yasu T, Ohya Y.]
通讯作者:
Ohya Y.
Bone marrow derived cells express higher angiotens in-converting enzyme 2 (ACE2) and its ability to attach in the brain of hypertensive rats
骨髓来源的细胞表达较高的血管紧张素转化酶 2 (ACE2) 及其在高血压大鼠大脑中的附着能力
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Masanobu Yamazato, Akio Ishida, Yoriko Yamazato, Atsushi Sakima, Takanori Yasu, Yusuke Ohya]
通讯作者:
Yusuke Ohya
骨髄由来細胞のレニンーアンジオテンシン系構成要素発現の特徴と脳での循環動態に及ぼす影響
骨髓源性细胞肾素-血管紧张素系统成分的表达特征及其对脑血流动力学的影响
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[山里正演, 石田明夫, 山里代利子, 崎間敦, 安隆則, 大屋祐輔]
通讯作者:
大屋祐輔
Role of bone marrow-derived cells in the brain on neurogenic hypertension
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批准号:24591232
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.41万
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财政年份:2012
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负责人:YAMAZATO Masanobu
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依托单位:
海外基金