Role of bone marrow-derived mononuclear cells on modulation of brain renin-angiotensin system

骨髓源性单核细胞对脑肾素-血管紧张素系统调节的作用

• 批准号: 21591059
• 负责人: YAMAZATO Masanobu
• 金额: $ 2.91万
• 依托单位: University of the Ryukyus
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591059/
• 关键词: 高血圧学; 中枢性血圧調節; 高血圧; 骨髄由来間葉系幹細胞; 脳室内投与; 骨髄由来単核球細胞

We hypothesized that decreased number or function of bone marrow(BM)-derived cells in the brain is related to neurogenic hypertension. Intracerebroventricular(icv) administration of DiI labeled BM-derived cells revealed that a long term attachment of DiI positive cell in the brain. Although icv administration of BM-derived cells did not alter blood pressure in hypertensive rats, higher expression of angiotensin converting enzyme 2(ACE2) and Mn-SOD of the BM-derived cells and its ability to attach in the brain suggest that BM-derived cells may serve as a mobile renin-angiotensin system modulator in the brain.

我们假设脑中骨髓来源的细胞数量或功能减少与神经源性高血压有关。侧脑室(Icv)注射DiI标记的骨髓来源细胞，发现DiI阳性细胞长期附着在脑内。虽然侧脑室注射BM来源的细胞并不改变高血压大鼠的血压，但BM来源的细胞的血管紧张素转换酶2(ACE2)和Mn-SOD的高表达及其在脑内的附着能力表明BM来源的细胞可能是脑内移动性肾素-血管紧张素系统的调节剂。

项目成果

Bone marrow derived cells express higher angiotensin-converting enzyme 2(ACE2) and its ability to attach in the brain of hypertensive rats

骨髓来源的细胞表达较高的血管紧张素转换酶2（ACE2）及其在高血压大鼠大脑中的附着能力

• 发表时间: 2011
• 作者: Yamazato M;Ishida A;Yamazato Y;Sakima A;Yasu T;Ohya Y.
• 通讯作者: Ohya Y.

骨髄由来細胞のレニンーアンジオテンシン系構成要素発現の特徴と脳での循環動態に及ぼす影響

骨髓源性细胞肾素-血管紧张素系统成分的表达特征及其对脑血流动力学的影响

• 发表时间: 2011
• 作者: 山里正演;石田明夫;山里代利子;崎間敦;安隆則;大屋祐輔
• 通讯作者: 大屋祐輔

Bone marrow derived cells express higher angiotens in-converting enzyme 2 (ACE2) and its ability to attach in the brain of hypertensive rats

骨髓来源的细胞表达较高的血管紧张素转化酶 2 (ACE2) 及其在高血压大鼠大脑中的附着能力

• 发表时间: 2011
• 作者: Masanobu Yamazato;Akio Ishida;Yoriko Yamazato;Atsushi Sakima;Takanori Yasu;Yusuke Ohya
• 通讯作者: Yusuke Ohya