Neurotoxicity of serum free light chains in patients with immunoglobulin-related amyloid polyneuropathy

点击翻译按钮获取中文摘要

The present study investigated whether or not plasma free light chains(FLC) of the patients with immunoglobulin-related amyloidosis have neurotoxicity. We cultured rat dorsal root ganglion neurons at various concentrations of purified FLC, and compared percentage of neurons with neirites, diameter of neurons, neurite number per neuron, length of the longest neurite in each neuron and total neurite length per neuron with those of controls. FLC of the immunoglobulin-related amyloidosis patients showed significant decreases in all of these parameters except for diameter of neurons compared with controls irrespective of the presence of clinically apparent peripheral neuropathy.