The missing link between proliferation and oxidative stress regulation in hematopoietic stem cells

点击翻译按钮获取中文摘要

Long-term dormancy in proliferation and strong defense response against oxidative stresses, prevent the senescence and tumorigenesis of hematopoietic stem cells. Here, we show that GATA2, a transcription factor essential for the life-long maintenance of hematopoietic stem cells, directly activates the transcription of several genes regulating cell proliferation, as well as genes regulating oxidative status. Furthermore, mice deficient in transcription factor Nrf2, which inclusively regulates oxidative stress response genes, show the different kinetics of hematopoietic stem/progenitor cells from wild type mice. These results indicate that cell proliferation and defense against oxidative stresses have shared regulatory components in hematopoietic stem cells.