Regulation of differentiation and proliferation of granulocytic precursors by C/EBP transcription factor

C/EBP转录因子对粒细胞前体细胞分化和增殖的调节

• 批准号: 21591246
• 负责人: HIRAI Hideyo
• 金额: $ 2.83万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591246/
• 关键词: 顆粒球; 転写因子; C/EBP; 分化; 増殖; 感染; C; EBP

We developed a novel flow cytometric method that successfully dissected mouse bone marrow cells undergoing granulopoiesis and found that C/EBPβis involved in the efficient amplification of early granulocyte precursors by regulating proliferation during candidemia-induced' emergency' granulopoiesis.

我们开发了一种新的流式细胞术方法，该方法成功地解剖了经历粒细胞生成的小鼠骨髓细胞，并发现C/EBPβ通过调节念珠菌诱导的“紧急”粒细胞生成期间的增殖而参与早期粒细胞前体的有效扩增。

项目成果

Involvement of C/EBPβ in BCR/ABL-dependent leukemogenesis

C/EBPβ 参与 BCR/ABL 依赖性白血病发生

• 发表时间: 2011
• 作者: Hayashi Y;et al
• 通讯作者: et al

CREB Is Involved in the Regulation of C/EBP & beta ; During 'emergency' Granulopoiesis

CREB参与C/EBP监管

• 发表时间: 2009
• 作者: Hirai H;Kamio N;Matsusue A;Ogino S;Kimura N;Satake S;Ashihara E;Maekawa T;Tenen DG;Imanishi J
• 通讯作者: Imanishi J

C/EBPファミリー転写因子による好中球産生の制御機構

C/EBP家族转录因子控制中性粒细胞产生的机制

• 发表时间: 2009
• 期刊: 医学のあゆみTOPICS 23(12)
• 作者: Fujishima S;Okano H;et al.;平位秀世
• 通讯作者: 平位秀世

Candidemia-Induced emergency granulopoiesis consists of successive dual waves triggered by the shift from C/EBPα to C/EBP β dependency

念珠菌血症诱导的紧急粒细胞生成由 C/EBPα 依赖性转变为 C/EBP β 依赖性触发的连续双波组成

• 发表时间: 2010
• 作者: Satake S;et al.
• 通讯作者: et al.

Use of bicistronic vectors in combination with flow cytometry to screen for effective small interfering RNA target sequences.

• DOI: 10.1016/j.bbrc.2010.02.033
• 发表时间: 2010-03-12
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Kamio, Naoka;Hirai, Hideyo;Ashihara, Eishi;Tenen, Daniel G.;Maekawa, Taira;Imanishi, Jiro
• 通讯作者: Imanishi, Jiro