Elucidation of immune regulation mechanisms by NF-kB for development of lymphocytes and macrophages.

阐明 NF-kB 对淋巴细胞和巨噬细胞发育的免疫调节机制。

• 批准号: 21591254
• 负责人: DOI Takahiro
• 金额: $ 2.91万
• 依托单位: The Institute of Physical and Chemical Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591254/
• 关键词: NF-kB; RelA; c-Rel; Hematopoiesis; Lym; phocytes; Macrophages Maturation; Apoptosis; Lymphocyte; Macrophage; Maturation arrest; Apopotsis; 造血機構; リンパ球; マクロファージ

We demonstrated that RelA and c-Rel were essential for regulation of cell-autonomous differentiation factors in hematopoiesis, because stem cells of lymphocytes and macrophages lacking RelA and c-Rel do not develop even in normal hematopoietic environment. And it was demonstrated that RelA and c-Rel functioned coordinately, because mice deficient of both of them showed pancytopenia, although mice lacking each of them did not. The main role of RelA and c-Rel in development of lymphocytes and macrophages cells from apoptosis. And beyond imagination, it was also demonstrated that RelA and c-Rel played the critical roles on development, not of lymphocytes and macrophages but also of megakaryocytes and erythrocytes.

我们证明，RelA和c-Rel是必不可少的调节细胞自主分化因子在造血，因为干细胞的淋巴细胞和巨噬细胞缺乏RelA和c-Rel不发展，即使在正常的造血环境。并且证明了RelA和c-Rel协同发挥作用，因为这两种蛋白都缺乏的小鼠表现出全血细胞减少，尽管这两种蛋白都缺乏的小鼠没有。RelA和c-Rel在淋巴细胞和巨噬细胞凋亡发育中的主要作用。出乎意料的是，RelA和c-Rel在淋巴细胞和巨噬细胞的发育过程中发挥了关键作用，但对巨核细胞和红细胞的发育也起着关键作用。

项目成果

NFkB/RelA positively functions on transcriptional activation of Foxp3 with TGF-beta signaling.

NFkB/RelA 通过 TGF-β 信号传导对 Foxp3 的转录激活发挥积极作用。

• 发表时间: 2010
• 作者: Yoshida;Y.;Hiroshi Fujiwara;土井貴裕
• 通讯作者: 土井貴裕

Deficiency of NF-kB/RelA subunit and tumor necrosis factor(TNF) both cause abnormal hamatopoiesis.

NF-kB/RelA亚基和肿瘤坏死因子(TNF)的缺乏都会导致造血异常。

• 发表时间: 2009
• 作者: 土井貴裕;三瀬節子
• 通讯作者: 三瀬節子

NF-kB inducing kinase(NIK) negatively regulates bone formation in vivo and in vitro

NF-kB 诱导激酶 (NIK) 负向调节体内和体外骨形成

• 发表时间: 2011
• 期刊: Endocrinology
• 影响因子: 4.8
• 作者: E. Jimi;T. Doi;et al
• 通讯作者: et al

The NF-kB RelA subunit confers resistance to Leishmania major by inducing NOS2 and Fas expression but not Th1 differentiation

NF-kB RelA 亚基通过诱导 NOS2 和 Fas 表达但不诱导 Th1 分化来赋予对重大利什曼原虫的抗性

• 发表时间: 2009
• 期刊: Journal of Immunology
• 影响因子: 4.4
• 作者: S. Mise;T. Doi;et al
• 通讯作者: et al

NF-kB/RelA positively functions on transcriptional activation of Foxp3 with TGF-b signaling

NF-kB/RelA 通过 TGF-b 信号传导对 Foxp3 转录激活发挥积极作用

• 发表时间: 2010
• 作者: 土井貴裕;三瀬節子
• 通讯作者: 三瀬節子