Elucidation of immune regulation mechanisms by NF-kB for development of lymphocytes and macrophages.

我们证明，RelA和c-Rel是必不可少的调节细胞自主分化因子在造血，因为干细胞的淋巴细胞和巨噬细胞缺乏RelA和c-Rel不发展，即使在正常的造血环境。并且证明了RelA和c-Rel协同发挥作用，因为这两种蛋白都缺乏的小鼠表现出全血细胞减少，尽管这两种蛋白都缺乏的小鼠没有。RelA和c-Rel在淋巴细胞和巨噬细胞发生凋亡中的主要作用。出乎意料的是，RelA和c-Rel在淋巴细胞和巨噬细胞的发育过程中发挥了关键作用，但对巨核细胞和红细胞的发育也起着关键作用。

We demonstrated that RelA and c-Rel were essential for regulation of cell-autonomous differentiation factors in hematopoiesis, because stem cells of lymphocytes and macrophages lacking RelA and c-Rel do not develop even in normal hematopoietic environment. And it was demonstrated that RelA and c-Rel functioned coordinately, because mice deficient of both of them showed pancytopenia, although mice lacking each of them did not. The main role of RelA and c-Rel in development of lymphocytes and macrophages cells from apoptosis. And beyond imagination, it was also demonstrated that RelA and c-Rel played the critical roles on development, not of lymphocytes and macrophages but also of megakaryocytes and erythrocytes.