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Development of a new stem cell transplantation regimen in the treatment of refractory autoimmune diseases

Development of a new stem cell transplantation regimen in the treatment of refractory autoimmune diseases
开发治疗难治性自身免疫性疾病的新干细胞移植方案
批准号:
21591266
负责人:
TSUKAMOTO Hiroshi
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
The objective was to determine the best regimen of autologous hematopoietic stem cell transplantation(auto-HSCT) for refractory autoimmune diseases. CD34+ selected auto-HSCT was more effective on skin sclerosis and more strongly associated with viral infection than unmanipulated auto-HSCT in patients with systemic sclerosis(SSc). The gene expression profile of lymphocytes more normalized in SSc patients who received CD34+ selected auto-HSCT than those who received unmanipulated auto-HSCT. In conclusion, CD34+ selected auto-HSCT should be applied in the treatment of refractory autoimmune diseases.
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会议论文
全身性硬化症に対する大量免疫抑制療法と自己末梢血純化CD34陽性細胞移植:術後5年間の臨床成績と免疫学的検討
大剂量免疫抑制治疗和自体外周血纯化CD34阳性细胞移植治疗系统性硬化症:术后5年临床结果和免疫学研究
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [塚本浩, 堀内孝彦, 三苫弘喜, 他]
通讯作者:
Infectious complications in patients receiving autologous CD34-selectedhematopoitic stem cell transplantation for severe autoimmune diseases
严重自身免疫性疾病患者接受自体CD34选择性造血干细胞移植的感染并发症
DOI: --
发表时间: 2009
期刊: Transpl infect dis 11
影响因子: --
作者: [Kohno K, Nagafuji K, Tsukamoto H, et al.]
通讯作者: et al.
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DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Miyazaki, Taisuke ; Yamasaki, Miwako ; Hashimoto, Kouichi, et, 松本美佐子,他]
通讯作者: 松本美佐子,他
DOI: 10.1097/maj.0b013e31822bdb65
发表时间: 2012-03-01
期刊: AMERICAN JOURNAL OF THE MEDICAL SCIENCES
影响因子: 3.1
作者: [Yamamoto, Tetsuro, Horiuchi, Takahiko, Akashi, Koichi]
通讯作者: Akashi, Koichi
21
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