Development of a new stem cell transplantation regimen in the treatment of refractory autoimmune diseases
Development of a new stem cell transplantation regimen in the treatment of refractory autoimmune diseases
批准号:
21591266
负责人:
TSUKAMOTO Hiroshi
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
点击翻译按钮获取中文摘要
英文摘要
The objective was to determine the best regimen of autologous hematopoietic stem cell transplantation(auto-HSCT) for refractory autoimmune diseases. CD34+ selected auto-HSCT was more effective on skin sclerosis and more strongly associated with viral infection than unmanipulated auto-HSCT in patients with systemic sclerosis(SSc). The gene expression profile of lymphocytes more normalized in SSc patients who received CD34+ selected auto-HSCT than those who received unmanipulated auto-HSCT. In conclusion, CD34+ selected auto-HSCT should be applied in the treatment of refractory autoimmune diseases.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
全身性硬化症に対する大量免疫抑制療法と自己末梢血純化CD34陽性細胞移植:術後5年間の臨床成績と免疫学的検討
大剂量免疫抑制治疗和自体外周血纯化CD34阳性细胞移植治疗系统性硬化症:术后5年临床结果和免疫学研究
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[塚本浩, 堀内孝彦, 三苫弘喜, 他]
通讯作者:
他
Infectious complications in patients receiving autologous CD34-selectedhematopoitic stem cell transplantation for severe autoimmune diseases
严重自身免疫性疾病患者接受自体CD34选择性造血干细胞移植的感染并发症
DOI:
--
发表时间:
2009
期刊:
Transpl infect dis 11
影响因子:
--
作者:
[Kohno K, Nagafuji K, Tsukamoto H, et al.]
通讯作者:
et al.
補体への招待
邀请补充
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Miyazaki, Taisuke ; Yamasaki, Miwako ; Hashimoto, Kouichi, et, 松本美佐子,他]
通讯作者:
松本美佐子,他
DOI:
10.1097/maj.0b013e31822bdb65
发表时间:
2012-03-01
期刊:
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
影响因子:
3.1
作者:
[Yamamoto, Tetsuro, Horiuchi, Takahiko, Akashi, Koichi]
通讯作者:
Akashi, Koichi
DOI:
10.1182/blood-2011-04-351965
发表时间:
2012-03-08
期刊:
BLOOD
影响因子:
20.3
作者:
[Niiro, Hiroaki, Jabbarzadeh-Tabrizi, Siamak, Akashi, Koichi]
通讯作者:
Akashi, Koichi
共 21 条
Identification of the new function of TNF induced by intramembrane proteases and the application to regulate inflammatory diseases.
-
批准号:24591465
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.41万
-
财政年份:2012
-
负责人:TSUKAMOTO Hiroshi
-
依托单位:
Functional analysis of BAFF, APRIL and their receptors, and the study of their role in the pathogenesis of autoimmune disease
-
批准号:18591113
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.57万
-
财政年份:2006
-
负责人:TSUKAMOTO Hiroshi
-
依托单位:
Optimum Design of a Diffuser Pump for High Efficiency and Favorite Characteristics
-
批准号:14350095
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.24万
-
财政年份:2002
-
负责人:TSUKAMOTO Hiroshi
-
依托单位:
Study of Pump Abnormal Characteristics from Prevention toward Suppression and Control
-
批准号:11555055
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$8.83万
-
财政年份:1999
-
负责人:TSUKAMOTO Hiroshi
-
依托单位:
Theoretical Prediction of Pressure Fluctuations in a Diffuser Pump based on Rotor-Stator Interaction Analysis
-
批准号:09450081
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$8.0万
-
财政年份:1997
-
负责人:TSUKAMOTO Hiroshi
-
依托单位:
Liquid-Solid Two Phase Flow in a Centrifugal Pump
-
批准号:08045040
-
项目类别:Grant-in-Aid for international Scientific Research
-
资助金额:$2.3万
-
财政年份:1996
-
负责人:TSUKAMOTO Hiroshi
-
依托单位:
INTELLIGENT AIRFOIL FOR PREVENTING FLOW SEPARATION
-
批准号:07555381
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$2.11万
-
财政年份:1995
-
负责人:TSUKAMOTO Hiroshi
-
依托单位:
Enhancement of Hydraulic Machinery by Use of Shape Memory Alloys
-
批准号:02555042
-
项目类别:Grant-in-Aid for Developmental Scientific Research (B)
-
资助金额:$5.12万
-
财政年份:1990
-
负责人:TSUKAMOTO Hiroshi
-
依托单位:
海外基金