Analysis on mouse model of Mycoplasma pneumoniae pneumonia, and its application to treatment.

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We generate a mouse model for Mycoplasma pneumoniae pneumonia, using M. pneumoniae extract(Mp extract). Cell culture experiments demonstrated that Mp extract activated intracellular signals, associated with p38, PI-3K and NF-kB. Mouse model histologically yielded the severe human M. pneumoniae pneumonia, as both share lymph-plasma cytic peri-bronchovascular infiltration. Our results on the effect of either dexamethasone, clarithromycin or both further demonstrated that Mycoplasma pneumoniae infection caused both NF-kB-dependent and NF-kB independent reactions.