Analysis of mechanisms of chronic GVHD post allo-SCT by marking with multicolor florescent proteins

通过多色荧光蛋白标记分析异基因 SCT 后慢性 GVHD 的机制

• 批准号: 21591379
• 负责人: ONODERA Masafumi
• 金额: $ 2.91万
• 依托单位: National Research Institute for Child Health and Development
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591379/
• 关键词: 小児血液学; 造血幹細胞移植; 移植片対宿主病; 蛍光色素; レトロウイルスベクター

The purpose of this study is to elucidate the mutual relations between immunocompetent cells such as T cells and antigen presenting cells until the GvHD onset after transplant using mice that GvHD develop due to difference of miHA. To address this issue, I have made virus vectors used in the study and performed transplants between mice with only different miHA(B6 and C3H) and analyzed mechanisms of acute or chronic GvHD.

本研究的目的是阐明免疫活性细胞如T细胞和抗原呈递细胞之间的相互关系，直到移植后发生GvHD，使用小鼠，GvHD发展由于miHA的差异。为了解决这个问题，我制作了研究中使用的病毒载体，并在仅具有不同miHA（B6和C3H）的小鼠之间进行了移植，并分析了急性或慢性GvHD的机制。

项目成果

Material obesity impairs hippocampal BDNF production and spatial learning performance in young mouse offspring.

物质性肥胖会损害幼鼠后代海马 BDNF 的产生和空间学习表现。

• 发表时间: 2010
• 期刊: Neurochem Int
• 影响因子: 4.2
• 作者: Tozuka Y;Kumon M;Wada E;Onodera M;Mochizuki H;Wada K.
• 通讯作者: Wada K.

Kinetics and effect of integrin expression in human CD34+ cells during MLV-derived retroviral transduction using a recombinant fibronectin for stem cell gene therapy

使用重组纤连蛋白进行干细胞基因治疗的 MLV 衍生逆转录病毒转导过程中人 CD34+ 细胞中整合素表达的动力学和影响

• 发表时间: 2009
• 期刊: Hum Gene Ther 20
• 作者: 宗村純平;藤野英俊;米田真紀子;中川雅生;Horiuchi Y
• 通讯作者: Horiuchi Y

A reciprocal regulation between PAX2 and PAX6

PAX2 和 PAX6 之间的相互调节

• 发表时间: 2009
• 作者: Tadokoro K;Azuma N;Onodera M
• 通讯作者: Onodera M

Intracellular estrogen receptor-binding fragment-associated antigen 9 exerts in vivo tumor-promoting effects via its coiled-coil region

• DOI: 10.3892/ijo.2011.1026
• 发表时间: 2011-07-01
• 期刊: INTERNATIONAL JOURNAL OF ONCOLOGY
• 影响因子: 5.2
• 作者: Maeyama, Yoshihiro;Otsu, Makoto;Ariga, Tadashi
• 通讯作者: Ariga, Tadashi

Heterozygous ITGA2B R995W mutation inducing a constitutive activation of the αIIbss3 receptor affects proplatelet formation and causes congenital macrothrombocytopenia

杂合 ITGA2B R995W 突变诱导 αIIbss3 受体组成型激活，影响前血小板形成并导致先天性巨血小板减少症

• 发表时间: 2011
• 期刊: Blood
• 影响因子: 20.3
• 作者: Kunishima S;Kashiwagi H;Otsu M;Takayam N;Eto K;Onodera M;Miyajima Y;Takamatsu Y;Suzumiya J;Matsubara K;Tomiyama Y;S Hidehiko
• 通讯作者: S Hidehiko