Proteomic analysis of ductus arteriosus by two-dimensional difference gel electrophoresis

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Increased PO2 contracts ductus arteriosus(DA) and relaxes pulmonary artery(PA). One of up-regulated proteins in DA under oxygenated condition was determined as peroxiredoxin 4, which regulates NF-kB activity via a modulation of I kB-a phosphorylation. Up-regulation of peroxiredoxin 4 in DA under oxygenated condition may contribute to the constriction of ductus arteriosus in response to change in the PO2 level after birth. Functional DA closure depends on gestational maturity. One of up-regulated proteins in the term DA was determined as reticulocalbin 3.Another identified up-regulated protein was tropomyosin 2 involved in muscle contraction. These proteins may accelerate migration of the smooth muscle cells from media to subendothelial space in the term DA, which contributes anatomical closure of the DA.