Roles for components of the feto-amniotic unit in maintaining pregnancy

胎儿羊膜单位的组成部分在维持妊娠中的作用

• 批准号: 21591423
• 负责人: ISHIMOTO Hitoshi
• 金额: $ 3万
• 依托单位: Tokai University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591423/
• 关键词: 羊膜; 胎児; 副腎; 羊水; コルチゾール; ミッドカイン; 妊娠維持; 胎児副腎; アンギオテンシン変換酵素

Our results demonstrate that factors that mediate the steroid-producing machinery in the outer zone of the human fetal adrenal gland(HFA), show zonal and/or ontogenic expression patterns relevant to the in vivo occurrence of cortisol and aldosterone synthesis at the periphery of the HFA in late gestation. Results also show that midkine, a heparin-binding growth factor, is likely secreted from the fetal lung into the amniotic fluid, and can suppress amniotic production of prostaglandin E2via COX2down-regulation, indicative of its role as a fetal signal for maintaining pregnancy.

我们的结果表明，调节人胎儿肾上腺(HFA)外区类固醇产生机制的因素，表现出与妊娠晚期HFA外围体内皮质醇和醛固酮合成相关的带状和/或个体起源的表达模式。结果还表明，中期因子是一种肝素结合生长因子，可能从胎肺分泌到羊水中，并通过下调COX2来抑制羊水中前列腺素E2的产生，这表明它是维持妊娠的胎儿信号。

项目成果

Iwata S 2011Laparoscopic cystectomy of ovarian teratoma in anti-NMDAR encephalitis : two case reports

Iwata S 2011腹腔镜卵巢畸胎瘤囊肿切除术治疗抗 NMDAR 脑炎：两例报告

• 发表时间: 2011
• 期刊: J Minim Invasive Gynecol
• 作者: Asai S;Ishimoto H;Yabuno A;Asada H;Seki M
• 通讯作者: Seki M

The Human Fetal Adrenal Gland : A Key Component of the Feto-Maternal Unit

人类胎儿肾上腺：胎儿-母体单位的关键组成部分

• 发表时间: 2010
• 作者: 粟津緑;飛彈麻里子;Ishimoto H
• 通讯作者: Ishimoto H

Ontogenic Expression of Angiotensin-Converting Enzyme in the Human Fetal Adrenal Gland : Implication in Angiotensin II-Mediated Aldosterone Synthesis

血管紧张素转换酶在人胎儿肾上腺中的个体表达：对血管紧张素 II 介导的醛固酮合成的影响

• 发表时间: 2011
• 作者: Doguchi K;Ishimoto H;Matsumoto T;Kondo A;Sato S;Miyazawa M;Minegishi K;Izumi S;Mikami M;Jaffe RB
• 通讯作者: Jaffe RB

Invitation to Fetal Endocrinology : Signals from the Fetus

胎儿内分泌学邀请：来自胎儿的信号

• 发表时间: 2010
• 作者: Muneoka K.;Kuwagata M.;Shirayama Y;Ogawa T;Shioda S;Ishimoto H
• 通讯作者: Ishimoto H

Expression of Ovary-Specific Acidic Protein in Steroidogenic Tissues: A Possible Role in Steroidogenesis

• DOI: 10.1210/en.2008-1584
• 发表时间: 2009-07-01
• 期刊: ENDOCRINOLOGY
• 影响因子: 4.8
• 作者: Matsumoto, Tadashi;Minegishi, Kazuhiro;Yoshimura, Yasunori
• 通讯作者: Yoshimura, Yasunori