Exploration of pathogenetic mechanism for hair diseases through dermal fibroblasts
Exploration of pathogenetic mechanism for hair diseases through dermal fibroblasts
批准号:
21591427
负责人:
NAKANO Hajime
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
Primary culture of the dermal fibroblasts derived from Hirosaki hairless rat (HHR-DF) develops multinuclear large fibroblasts after multiple culture passages. These cells have low proliferation ability. Several growth stimuli including calf serum, TGF-beta, and bFGF failed to promote cell proliferation of HHR-DF. Artificial skin defect on the dorsal skin of HHR showed retarded wound healing. These results suggest that HHR-DF has an impaired sensitivity to growth stimuli.
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Characterization of Hair Follicles in Hirosaki Hairless Rats with Deletion of Basic Hair Keratin Genes. Enlarged Medulla, Loss of Cuticle and Long Catagen
基本毛发角蛋白基因缺失的弘前无毛大鼠毛囊的表征。
DOI:
--
发表时间:
2009
期刊:
Hirosaki Medical Journal
影响因子:
--
作者:
[Akita M, Nanashima N, Yamada T, Nakano H, Shimizu T, Fan Y, Tsuchida S]
通讯作者:
Tsuchida S
Leukemia cutis is an early sign of blast transformation that may mimic a common skin disease : sycosis-like eruptions in chronic myelomonocvtic leukemia.
皮肤白血病是原始细胞转化的早期征兆,可能类似于一种常见的皮肤病:慢性粒细胞白血病的昏厥样皮疹。
DOI:
--
发表时间:
2010
期刊:
J Dermatol
影响因子:
3.1
作者:
[Sonoko Takeuchi, et al.]
通讯作者:
et al.
ヘアケラチン遺伝子の欠損がある弘前ヘアレスラットの毛構造の変化、毛周期の変化
毛发角蛋白基因缺陷弘前无毛大鼠毛发结构及毛发周期的变化
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Kuwagata M, Ogawa T, Nagata T, Shioda S, 秋田美季]
通讯作者:
秋田美季
Buschke-Ollendorff syndrome associated with hypertrophic scar formation : a possible role for LEMD3 mutation
Buschke-Ollendorff 综合征与增生性疤痕形成相关:LEMD3 突变的可能作用
DOI:
10.1111/j.1365-2133.2011.10691.x
发表时间:
2012
期刊:
Br J Dermatol
影响因子:
--
作者:
[Korekawa A, Nakano H, Toyomaki Y, Takiyoshi N, Rokunohe D, Akasaka E, Nakajima K, Sawamura D]
通讯作者:
Sawamura D
ヘアケラチン遺伝子の欠損がある弘前ヘアレスラット(HHR)の毛構造の変化、毛周期の変化
毛发角蛋白基因缺陷的弘前无毛大鼠(HHR)毛发结构和毛发周期的变化
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[熊谷文明, 臼見憲司, 丸茂秀樹, 斉藤義明, 永田伴子, 桑形麻樹子, 秋田美季]
通讯作者:
秋田美季
共 7 条
COL7A1 expression in the peripheral blood mononuclear cells
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批准号:15K09739
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.08万
-
财政年份:2015
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负责人:NAKANO Hajime
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依托单位:
海外基金